alexa Stable Stretched Suspended DNA Molecules
ISSN: 2169-0111

Advancements in Genetic Engineering
Open Access

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Stable Stretched Suspended DNA Molecules

Manola Moretti1, Tania Limongi1*, Monica Marini1, Francesco Gentile2, Andrea Giugni1, Bruno Torre1, Marco Allione1, Luca Tirinato1, Gobind Das1, Gerardo Perozziello2, Patrizio Candeloro2 and Enzo di Fabrizio1
1SMILEs Lab, PSE and BESE Divisions, King Abdullah University of Science and Technology, Thuwal, Saudi Arabia
2University of Magna Graecia, Viale Europa, Germaneto, Italy
Corresponding Author : Tania Limongi
SMILEs Lab, PSE and BESE Divisions
King Abdullah University of Science and Technology
Thuwal, 23955-6900, Kingdom of Saudi Arabia
Tel: 00393283366593
E-mail: [email protected]
Received: November 05, 2015 Accepted: January 23, 2016 Published: January 30, 2016
Citation: Moretti M, Limongi T, Marini M, Gentile F, Giuni A, (2016) Stable Stretched Suspended DNA Molecules. Adv Genet Eng 5:i102. doi: 10.4172/2169-0111.1000i102
Copyright: © 2016 Moretti M, et al. This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.
 

Abstract

The elastic properties of nucleic acids (DNA and RNA) are strictly related to their biological function, especially in the case of DNA. The elastic properties control their bending and twisting by ensuring that long molecules can fit into the nucleus of a cell and that, proteins and drugs, can regulate all the cellular processes by means of effective bindings. Accurate elasticity response measurement of DNA molecules to chemo/ mechanical stress, is usually determined in pulling experiments by investigating secondary structure formation and conformational transitions. Many techniques are available for DNA/RNA manipulation such as optical and magnetic tweezers.

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