Staphylococcal Biofilms:Challenges in the Discovery of Novel Antiinfective Agents
Department STEMBIO, Università degli Studi di Palermo, Via Archirafi 32, 90123-Palermo, Italy
- *Corresponding Author:
- Dr. Domenico Schillaci
Università degli Studi di Palermo
Via Archirafi 32, 90123-Palermo, Italy
E-mail: [email protected]
Received Date: March 30, 2011; Accepted Date: June 17, 2011; Published Date: June 21, 2011
Citation: Schillaci D (2011) Staphylococcal Biofilms: Challenges in the Discovery of Novel Anti-infective Agents. J Microbial Biochem Technol 3: iv-vi. doi: 10.4172/1948-5948.100000e4
Copyright: © 2011 Schillaci D. This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.
Staphylococci can induce a wide spectrum of infectious diseases that are associated with remarkable morbidity and mortality . In fact, community and hospital-acquired methicillin resistant Staphylococcus aureus (MRSA) is a major health problem that has created a pressing need for novel therapeutic options . Importantly, pathogenic staphylococci have not only an amazing ability to acquire resistance to antibiotics, but also to form biofilms, bacterial communities that grow on surfaces and are surrounded by a self-produced polymer matrix. This latter characteristic is likely the most important virulence factor of staphylococci in the development of the chronic form of infectious diseases in humans such as otitis media, osteomyelitis, endophtalmitis, urinary tract infections, acute septic arthritis, native valve endocarditis, burn or wound infections and cystic fibrosis associated infections.