alexa State of The Art in Clinical Management of Channelopathies and Risk of Sudden Cardiac Death | OMICS International| Abstract
ISSN: 1747-0862

Journal of Molecular and Genetic Medicine
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  • J Mol Genet Med 2019, Vol 13(1): 411
  • DOI: 10.4172/1747-0862.1000411

State of The Art in Clinical Management of Channelopathies and Risk of Sudden Cardiac Death

Malagù M1*, Balla C1, Gualandi F2, Vitali F1, Selvatici R2, Ferlini A2, Zaraket F1, Del Franco A1, Cimaglia P3, Squeri A3, Ferrari R3 and Bertini M1
1Cardiology Unit, Azienda Ospedaliero-Universitaria di Ferrara, Italy
2Medical Genetics Logistic Unit, Azienda Ospedaliero-Universitaria di Ferrara, Italy
3Maria Cecilia Hospital, GVM Care & Research, Cotignola, Italy
*Corresponding Author : Dr. Malagù M, Cardiology Unit, Azienda Ospedaliero-Universitaria di Ferrara, Via Aldo Moro 8, 44124 Cona, Ferrara, Italy, Tel: +39 532 236269, Email: [email protected]

Received Date: Feb 25, 2019 / Accepted Date: Mar 11, 2019 / Published Date: Mar 18, 2019

Abstract

Major arrhythmias and sudden cardiac death in young and apparently healthy people are usually the first manifestation of cardiac channelopathies (CC). CC include long QT syndrome, short QT syndrome, Brugada syndrome and catecholaminergic polymorphic ventricular tachycardia. Identification and proper management of these diseases is a challenge for the clinical cardiologists, which could benefit from collaboration with geneticists and other physicians due to relevant genetic, molecular, biologic and psychologic implications. Medical awareness of these issues is growing fast as clinical research provides continue update. In this paper, we provide a comprehensive review of CC. The genes associated with CC and their relative role are here illustrated and summarized.

Keywords: Cardiac death; Tachycardia; Gene-by-gene; Genetic heterogeneity

Citation: Malagù M, Balla C, Gualandi F, Vitali F, Selvatici R, et al. (2019) State of The Art in Clinical Management of Channelopathies and Risk of Sudden Cardiac Death. J Mol Genet Med 13:411. Doi: 10.4172/1747-0862.1000411

Copyright: © 2019 Malagù M, et al. This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.

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