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Statins as Potentially Neuroprotective Agents: A Review | OMICS International | Abstract
ISSN: 2155-6148

Journal of Anesthesia & Clinical Research
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Review Article

Statins as Potentially Neuroprotective Agents: A Review

Anuradha Patel1* and Sergey V Pisklakov2*

1Associate Professor, Section Chief, Pediatric Anesthesia, Department of Anesthesiology and Perioperative Care New Jersey School of Medicine, Newark, New Jersey, USA

2Assistant Professor, Director of Neuroanesthesia Service, Chairman of Clinical Competence Committee, Department of Anesthesiology and Perioperative Care, New Jersey School of Medicine, Newark, New Jersey, USA

*Corresponding Authors:
Anuradha Patel
Associate Professor, Section Chief
Pediatric Anesthesia, Department of Anesthesiology and Perioperative Care
New Jersey School of Medicine, 185 S Orange Ave, MSB E-552, Newark, NJ 07101, USA
Tel: 973 972 5255
Fax: 9739724172
E-mail: [email protected]
Yong-Gook Jung
Department of Economics
Wayne State University
656 W. Kirby Street
Detroit, MI 48202, USA
Tel: +1 313 577 3231
Fax: +1 313 577 9564
E-mail: [email protected]

Received date: September 13, 2012; Accepted date: October 23, 2012; Published date: October 29, 2012

Citation: Patel A, Pisklakov SV (2012) Statins as Potentially Neuroprotective Agents: A Review. J Anesth Clin Res 3:251. doi: 10.4172/2155-6148.1000251

Copyright: © 2012 Patel A, et al. This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.


The aim of this literature review is to assess the experimental and clinical evidence regarding potential neuroprotective effects of statins and their possible perioperative benefit. Statins are drugs used to control cholesterol disorders and prevent cardiovascular diseases by four mechanisms: improvement of endothelial function, modulation of inflammatory responses, maintenance of plaque stability, and prevention of thrombus formation. It is possible that these various effects may also be neuroprotective. The anti-inflammatory effects of statins on endothelial cell mechanisms are better understood than their role in neuroprotection or tumoral apoptosis and evidence is only just emerging that statins may be beneficial. Data regarding perioperative use of statins in neurosurgery is scarce, controversial and inconclusive since there is a lack of convincing randomized, prospective clinical trials. More trials in humans are needed to determine whether statins could contribute to the current management of neurosurgical diseases. Not much is known about utilizing statins as a prophylactic treatment and some would probably advocate that we should be treating ‘at risk’ patients with statins perioperatively or at least it is important to try to put this into a clinical perspective.


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