alexa Statins Therapy: Effects on Plasma Fibrinogen Levels and Fibrinolysis
ISSN: 2161-0509

Journal of Nutritional Disorders & Therapy
Open Access

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Research Article

Statins Therapy: Effects on Plasma Fibrinogen Levels and Fibrinolysis

Rita Marchi Cappelletti*

Venezuelan Institute for Scientific Research, Center for Experimental Medicine, Pathophysiology Laboratory, Developmental Biology Section of Hemostasis, Bolivarian Republic of Venezuela, Caracas 1020A, PO Box 20632, Venezuela

*Corresponding Author:
Rita Marchi Cappelletti
Venezuelan Institute for Scientific Research
Center for Experimental Medicine, Pathophysiology Laboratory
Developmental Biology Section of Hemostasis
Bolivarian Republic of Venezuela, Caracas 1020A
PO Box 20632, Venezuela
Tel: +58-212-5041526
Fax: +58-212-5041086
E-mail: [email protected]

Received date November 25, 2011; Accepted date February 07, 2012; Published dateFebruary 09, 2012

Citation: Marchi RC (2012) Statins Therapy: Effects on Plasma Fibrinogen Levels and Fibrinolysis. J Nutr Disorders Ther S6:001. doi:10.4172/2161-0509.S6-001

Copyright: © 2012 Marchi RC. This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.

Abstract

Elevated plasma fibrinogen levels have been identified as an independent and strong risk factor for cardiovascular disease. At present, there are no selective oral agents that lower fibrinogen; however different drugs can influence its levels as ticlopidine (inhibitor of platelet aggregation) and fibrates (lipid lowering drugs). Statins lower cholesterol by inhibiting HMG-CoA (3-hydroxy-3-methylglutaryl-coenzyme A) reductase, which catalyzes the conversion of HMGCoA to mevalonate, the rate limiting step in cholesterol biosynthesis. In addition to lowering cholesterol, several non-lipids related benefits of statins have been reported. Briefly, statins improve endothelial function, modulate the inflammatory response, may stabilize atherosclerotic plaques, restrain thrombus formation, and others. Many of these are mediated by their ability to block the synthesis of important isoprenoid intermediates, which serve as lipid attachments for a variety of intracellular signaling molecules (Rho, Ras, and Rac). The beneficial effect of statin on plasma fibrinogen concentration still controversial. Although several studies have shown a mild decrease in plasma fibrinogen (mostly when the Clauss method is used), many others fail to find an effect of statins on plasma fibrinogen concentration. In vitro studies using different cell types have shown that statins increase tPA and decrease PAI-1 levels; however, clinical results are ambiguous. Statins modify fibrin structure leading to increased clot lysis rate and clot permeability, by decreasing tissue factor expression that alters thrombin formation.
 

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