Statistical Study on Serum CRP levels in Aggressive & Chronic Periodontitis:Pre & Post Non-Surgical Periodontal Therapy
Varshal J Barot* and Sarath Chandran
Department of Periodontics & Implantology, Manubhai Patel Dental College & Hospital, Vadodara, Gujarat, India
- *Corresponding Author:
- Varshal J Barot, MDS
Department of Periodontics & Implantology
Manubhai Patel Dental College & Hospital
Vadodara, Gujarat, India
Tel: +91 9558805347
E-mail: [email protected]
Received Date: September 07, 2015, Accepted Date: October 05, 2015, Published Date: October 14, 2015
Citation: Barot JV, chandran S (2015) Statistical Study on Serum CRP levels in Aggressive & Chronic Periodontitis: Pre & Post Non-Surgical Periodontal Therapy. Anaplastology 4:152. doi:10.4172/2161-1173.1000152
Copyright: © 2015 Barot JV, et al. This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.
Background: Elevated serum C-reactive protein (CRP) is regarded as a risk predictor for cardiovascular diseases. A positive association between circulating CRP levels and periodontal disease may be responsible. The aim of this study was to determine the effect of non-surgical periodontal therapy on serum CRP, WBC and OHI-S level in patients with aggressive and chronic periodontitis.
Methods: Total 57 subjects, divided into 3 groups based on the diagnosis into: Group A- aggressive periodontitis (n=17), Group B- chronic periodontitis (n=20) and Group C- non-periodontitis (n=20). After clinical data were recorded, venous blood was taken at baseline and 1 month after nonsurgical periodontal therapy. Periodontal examination included probing depth at baseline and OHI-S level was recorded at baseline and after 1 month. Blood was analysed to determine serum CRP and white blood cells (WBC) count.
Results: Mean WBC level: In group A, at baseline is 1.03E4 ± 1850.85 whereas it is 7976.47 ± 1538.47 after one month and in group B, at baseline is 9464.00 ± 1904.62 whereas it is 8510.00 ± 1778.79 after one month.
Mean OHI-S level: In group A, at baseline was 2.8847 ± 0.83 whereas it was 0.7029 ± 0.30 after one month and in group B, at baseline was 3.1480 ± 0.87 whereas it was 0.6465 ± 0.40 after one month. Treatment resulted in reduction of WBC count and oral hygiene index- simplified (OHI-S) score levels (p<0.05).
Mean CRP level: In group A, at baseline was 5.091 ± 10.02 whereas it was 3.0153 ± 3.37 after one month and in group B, at baseline was 2.658 ± 1.82 whereas it was 3.0030 ± 2.24 after one month. In group C at baseline was 1.917 ± 0.79. However, there were statistically no significant changes in levels of serum CRP in aggressive and chronic periodontitis (p>0.05).
Conclusion: Both forms of periodontitis are associated with increased systemic inflammatory response with aggressiveness of disease progression, but improvement in periodontal health did not influence the levels of serum CRP.