Stem Cell Transplantation for Treatment of Intractable Diseases
Susumu Ikehara* and Ming Li
Department of Stem Cell Disorders, Kansai Medical University, Hirakata City, Osaka, Japan
- *Corresponding Author:
- Susumu Ikehara
Department of Stem Cell Disorders
Kansai Medical University
Hirakata City, Osaka 570-1010, Japan
E-mail: [email protected]
Received Date: September 13, 2013; Accepted Date: November 03, 2013; Published Date: November 05, 2013
Citation: Ikehara S, Li M (2013) Stem Cell Transplantation for Treatment of Intractable Diseases. J Blood Lymph 3:111. doi:10.4172/2165- 7831.1000111
Copyright: © 2013 Ikehara S, et al. This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.
Hemopoietic stem cells (HSCs) can be harvested from the bone marrow, peripheral blood or umbilical cord blood. HSC transplantation is used to treat hematologic and lymphoid cancers and other disorders. Some reports have indicated that Bone Marrow Transplantation (BMT) might cure these intractable diseases--including hematological disorders, autoimmune diseases and age-associated diseases. Intra bone marrow- BMT (IBM-BMT) has been proven to be a powerful strategy for allogeneic BMT due to the rapid hemopoietic recovery and the complete restoration of T cell functions. In this review, we summarize the findings of our studies of IBM-BMT to treat some intractable diseases, including cancers such as leukemia, autoimmune diseases such as rheumatoid arthritis and autoimmune pancreatitis, age-related diseases such as osteoporosis and Alzheimer’s disease in mouse models.