Stem Cells and Cancer
Awol Mekonnen Ali*
College of Medicine, Institute of Medicine and Health science, Debre Birhan University, Ethiopia
- *Corresponding Author:
- Ali AM
College of Medicine
Institute of Medicine and Health science
Debre Birhan University, Ethiopia
Tel: + 251116815440
E-mail: [email protected]
Received date: September 15, 2016; Accepted date: October 27, 2016; Published date: October 28, 2016
Citation: Ali AM (2016) Stem Cells and Cancer. J Cell Sci Ther 7:255. doi:10.4172/2157-7013.1000255
Copyright: © 2016 Ali AM. This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.
Stem cells are undifferentiated cells that can differentiate into specialized cell and can divide to produce more stem cells. The concept of cancer stem cells has been discussed in the scientific literature since the 19th century. Circumstantial evidence suggests that most tumors are heterogeneous and contain a small population of cancer stem cells that exhibit distinctive self-renewal, proliferation and differentiation capabilities, which are believed to play a crucial role in tumor progression, drug resistance, recurrence and metastasis in multiple malignancies. Unlike normal adult stem cells that remain constant in number, cancer stem cells can increase in number as tumors grow, and give rise to progeny that can be both locally invasive and colonize distant sites-the two hallmarks of malignancy. Rapid advances in the cancer stem cell feld have provided cause for optimism for the development of more reliable cancer therapies in the future. Strategies aimed at effcient targeting of cancer stem cells are becoming important for monitoring the progress of cancer therapy and for evaluating new therapeutic approaches.