Stem Cells and the Translational Control of Differentiation: Following the Ribosome Footprints
Patrícia Shigunov, Bruno Dallagiovanna and Fabíola Holetz*
Instituto Carlos Chagas, FIOCRUZ-PR, Brazil
- Corresponding Author:
- Fabíola Holetz
Instituto Carlos Chagas
FIOCRUZ-PR, Curitiba, Brazil
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E-mail: [email protected]
Received date: May 13, 2014; Accepted date: May 29, 2014; Published date: June 20, 2014
Citation: Shigunov P, Dallagiovanna B, Holetz F (2014) Stem Cells and the Translational Control of Differentiation: Following the Ribosome Footprints. J Mol Genet Med 8:111. doi: 10.4172/1747-0862.1000111
Copyright: © 2014 Shigunov P, et al. This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author(s) and source are credited.
Stem cells have been proposed as a promising source for cell therapy. Understanding the biological processes that commit stem cells to differentiate into a particular cell type is essential for the successful repair of injured tissue, and even for whole organogenesis. Cellular differentiation can be modeled as a network of regulatory circuits that direct various steps of gene expression and mediate the spatiotemporal control of a cell’s proteome. In this minireview, we discuss the current aspects of posttranscriptional regulation of gene expression in stem cells, with an emphasis on translational regulation. Several data supports the idea that a significant percentage of genes have their expression controlled at the translational level during stem cell commitment and differentiation. We focus on strategies using polysome and ribosome profiling to measure translational rates and to unravel the dynamics of this process.