Stem Cells for Neurovascular Repair in StrokeKazutaka Shinozuka, Travis Dailey, Naoki Tajiri, Hiroto Ishikawa, Dae Won Kim, Mibel Pabon, Sandra Acosta, Yuji Kaneko, and Cesar V Borlongan*
Department of Neurosurgery and Brain Repair, University of South Florida College of Medicine, 12901 Bruce B. Downs Blvd. MDC78, Tampa, Florida 33612, USA
- *Corresponding Author:
- Dr. Cesar V. Borlongan
University of South Florida College of Medicine
Department of Neurosurgery and Brain Repair, Tampa, USA
E-mail: [email protected]
Received date: April 12, 2013; Accepted date: April 29, 2013; Published date: May 01, 2013
Citation: Shinozuka K, Dailey T, Tajiri N, Ishikawa H, Kim DW, et al. (2013) Stem Cells for Neurovascular Repair in Stroke. J Stem Cell Res Ther S4:004. doi:10.4172/2157-7633.S4-004
Copyright: © 2013 Shinozuka K, et al. This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.
Stem cells exert therapeutic effects against ischemic stroke via transplantation of exogenous stem cells or stimulation of endogenous stem cells within the neurogenic niches of subventricular zone and subgranular zone, or recruited from the bone marrow through peripheral circulation. In this paper, we review the different sources of stem cells that have been tested in animal models of stroke. In addition, we discuss specific mechanisms of action, in particular neurovascular repair by endothelial progenitor cells, as key translational research for advancing the clinical applications of stem cells for ischemic stroke.