alexa Stereochemistrical Determination of Dexlansoprazole by Optical Rotation, ECD and 13C-NMR | OMICS International
ISSN: 2161-0444

Medicinal Chemistry
Open Access

Like us on:
OMICS International organises 3000+ Global Conferenceseries Events every year across USA, Europe & Asia with support from 1000 more scientific Societies and Publishes 700+ Open Access Journals which contains over 50000 eminent personalities, reputed scientists as editorial board members.

Open Access Journals gaining more Readers and Citations

700 Journals and 15,000,000 Readers Each Journal is getting 25,000+ Readers

This Readership is 10 times more when compared to other Subscription Journals (Source: Google Analytics)

Research Article

Stereochemistrical Determination of Dexlansoprazole by Optical Rotation, ECD and 13C-NMR

Zhixu Zhou1, Linwei Li1, Ning Yan1, Lei Du1, Changshan Sun2 and Tiemin Sun1*

1Key Laboratory of Structure-Based Drug Design and Discovery, Shenyang Pharmaceutical University, Shenyang, PR China

2Department of Pharmacy, Shenyang Pharmaceutical University, Shenyang, PR China

*Corresponding Author:
Tiemin Sun
Key Laboratory of Structure-Based Drug Design and Discovery
Shenyang Pharmaceutical University, Shenyang, PR China
Tel: 86-13386838360
E-mail: [email protected]26.com

Received date: May 20, 2015; Accepted date: June 09, 2015; Published date: June 12, 2015

Citation: Zhou Z, Li L, Yan N, Du L, Sun C, et al. (2015) Stereochemistrical Determination of Dexlansoprazole by Optical Rotation, ECD and 13C-NMR. Med chem 5:235-240. doi:10.4172/2161-0444.1000270

Copyright: © 2015 Zhou Z, et al. This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.

Abstract

Dexlansoprazole is an outstandingproton pump inhibitors, which is a chiral sulfoxide. We firstly report determination of the absolute configuration (AC) of dexlansoprazole by the combination of experimental and calculated optical rotation (OR), electronic circular dichroism (ECD) and 13C-NMR. The high agreement between theoretical and experimental data illustrates that this method would be used to determine the absolute configuration of chiral sulfoxide.

Keywords

Peer Reviewed Journals
 
Make the best use of Scientific Research and information from our 700 + peer reviewed, Open Access Journals
International Conferences 2017-18
 
Meet Inspiring Speakers and Experts at our 3000+ Global Annual Meetings

Contact Us

Agri & Aquaculture Journals

Dr. Krish

[email protected]

1-702-714-7001Extn: 9040

Biochemistry Journals

Datta A

[email protected]

1-702-714-7001Extn: 9037

Business & Management Journals

Ronald

[email protected]

1-702-714-7001Extn: 9042

Chemistry Journals

Gabriel Shaw

[email protected]

1-702-714-7001Extn: 9040

Clinical Journals

Datta A

[email protected]

1-702-714-7001Extn: 9037

Engineering Journals

James Franklin

[email protected]

1-702-714-7001Extn: 9042

Food & Nutrition Journals

Katie Wilson

[email protected]

1-702-714-7001Extn: 9042

General Science

Andrea Jason

[email protected]

1-702-714-7001Extn: 9043

Genetics & Molecular Biology Journals

Anna Melissa

[email protected]

1-702-714-7001Extn: 9006

Immunology & Microbiology Journals

David Gorantl

[email protected]

1-702-714-7001Extn: 9014

Materials Science Journals

Rachle Green

[email protected]

1-702-714-7001Extn: 9039

Nursing & Health Care Journals

Stephanie Skinner

[email protected]

1-702-714-7001Extn: 9039

Medical Journals

Nimmi Anna

[email protected]

1-702-714-7001Extn: 9038

Neuroscience & Psychology Journals

Nathan T

[email protected]

1-702-714-7001Extn: 9041

Pharmaceutical Sciences Journals

Ann Jose

[email protected]

1-702-714-7001Extn: 9007

Social & Political Science Journals

Steve Harry

[email protected]

1-702-714-7001Extn: 9042

 
© 2008- 2017 OMICS International - Open Access Publisher. Best viewed in Mozilla Firefox | Google Chrome | Above IE 7.0 version