Stereochemistrical Determination of Dexlansoprazole by Optical Rotation, ECD and 13C-NMR
- *Corresponding Author:
- Tiemin Sun
Key Laboratory of Structure-Based Drug Design and Discovery
Shenyang Pharmaceutical University, Shenyang, PR China
E-mail: [email protected]
Received date: May 20, 2015; Accepted date: June 09, 2015; Published date: June 12, 2015
Citation: Zhou Z, Li L, Yan N, Du L, Sun C, et al. (2015) Stereochemistrical Determination of Dexlansoprazole by Optical Rotation, ECD and 13C-NMR. Med chem 5:235-240. doi:10.4172/2161-0444.1000270
Copyright: © 2015 Zhou Z, et al. This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.
Dexlansoprazole is an outstandingproton pump inhibitors, which is a chiral sulfoxide. We firstly report determination of the absolute configuration (AC) of dexlansoprazole by the combination of experimental and calculated optical rotation (OR), electronic circular dichroism (ECD) and 13C-NMR. The high agreement between theoretical and experimental data illustrates that this method would be used to determine the absolute configuration of chiral sulfoxide.