Medicinal Chemistry

Stereochemistrical Determination of Dexlansoprazole by Optical Rotation, ECD and ¹³C-NMR

Abstract

Zhixu Zhou, Linwei Li, Ning Yan, Lei Du, Changshan Sun and Tiemin Sun

Dexlansoprazole is an outstandingproton pump inhibitors, which is a chiral sulfoxide. We firstly report determination of the absolute configuration (AC) of dexlansoprazole by the combination of experimental and calculated optical rotation (OR), electronic circular dichroism (ECD) and 13C-NMR. The high agreement between theoretical and experimental data illustrates that this method would be used to determine the absolute configuration of chiral sulfoxide.