alexa Stereotactic Radiotherapy in the Management of Epilepsy | OMICS International | Abstract
ISSN: 2376-0281

International Journal of Neurorehabilitation
Open Access

OMICS International organises 3000+ Global Conferenceseries Events every year across USA, Europe & Asia with support from 1000 more scientific Societies and Publishes 700+ Open Access Journals which contains over 50000 eminent personalities, reputed scientists as editorial board members.

Open Access Journals gaining more Readers and Citations
700 Journals and 15,000,000 Readers Each Journal is getting 25,000+ Readers

This Readership is 10 times more when compared to other Subscription Journals (Source: Google Analytics)

Review Article

Stereotactic Radiotherapy in the Management of Epilepsy

MS Mat Samuji* and Frederik Vernimmen

Department of Radiation Oncology, Cork University Hospital, Wilton, Cork, Ireland

*Corresponding Author:
Mohd. Syafawi Mat Samuji
Department of Radiation Oncology
Cork University Hospital, Wilton
Cork, Ireland
Tel: 00-353- 863522357
Fax: 00-353-21-4921346
E-mail: [email protected]

Received date: July 19, 2014; Accepted date: August 30, 2014; Published date: September 10, 2014

Citation: Samuji MSM. Vernimmen F (2014) Stereotactic Radiotherapy in the Management of Epilepsy. Int J Neurorehabilitation 1:118. doi:10.4172/2376-0281.1000118

Copyright: © 2014 Samuji MSM, et al. This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.

Abstract

Although the main stay of epileptic therapy is pharmacological certain forms of epilepsy such as temporal lobe epilepsy and epilepsy associated with benign diseases of the brain can also be successfully managed surgically. A neurosurgical procedure has the advantage of an immediate therapeutic result. When surgery is not possible, therapeutic irradiation is an option, but there is always a latent time between the radiation and the improvement in the epilepsy. This radiation is under the form of photon radiation produced by Cobalt sources in a Gamma knife® or by Linear accelerators. Special beam collimation techniques produce a sharp beam allowing for a high dose to be delivered to the target without side effects on the normal surrounding brain. The desired therapeutic effect comes from the late radiation effects, and hence is not immediate. The absorption in tissue of photon radiation is such that there is always an exit dose, and this contributes to radiation side effects on normal tissue. Particle radiation beams such as a proton beam have a dose absorption advantage over photons because there is a lower entry dose and no exit dose. This has the potential to treat the brain with a lower risk of side effects, and a lower integral dose. Presently radiation dose selection is aimed at causing tissue destruction in the target volume. Dose schedules that do not cause tissue necrosis but have a neurophysiologic therapeutic effect are presently under investigation. New irradiation technologies such as micro photon beams using synchrotron radiation and mini proton beams are been studied especially for their potential in epilepsy therapy. These technologies could greatly improve the therapeutic ratio as they cause no damage to brain tissue. If proven to have a therapeutic effect these new developments would expand the role of radiation in managing epilepsy.

Keywords

Peer Reviewed Journals
 
Make the best use of Scientific Research and information from our 700 + peer reviewed, Open Access Journals
International Conferences 2018-19
 
Meet Inspiring Speakers and Experts at our 3000+ Global Annual Meetings

Contact Us

Agri & Aquaculture Journals

Dr. Krish

[email protected]

+1-702-714-7001Extn: 9040

Biochemistry Journals

Datta A

[email protected]

1-702-714-7001Extn: 9037

Business & Management Journals

Ronald

[email protected]

1-702-714-7001Extn: 9042

Chemistry Journals

Gabriel Shaw

[email protected]

1-702-714-7001Extn: 9040

Clinical Journals

Datta A

[email protected]

1-702-714-7001Extn: 9037

Engineering Journals

James Franklin

[email protected]

1-702-714-7001Extn: 9042

Food & Nutrition Journals

Katie Wilson

[email protected]

1-702-714-7001Extn: 9042

General Science

Andrea Jason

[email protected]

1-702-714-7001Extn: 9043

Genetics & Molecular Biology Journals

Anna Melissa

[email protected]

1-702-714-7001Extn: 9006

Immunology & Microbiology Journals

David Gorantl

[email protected]

1-702-714-7001Extn: 9014

Materials Science Journals

Rachle Green

[email protected]

1-702-714-7001Extn: 9039

Nursing & Health Care Journals

Stephanie Skinner

[email protected]

1-702-714-7001Extn: 9039

Medical Journals

Nimmi Anna

[email protected]

1-702-714-7001Extn: 9038

Neuroscience & Psychology Journals

Nathan T

[email protected]

1-702-714-7001Extn: 9041

Pharmaceutical Sciences Journals

Ann Jose

[email protected]

1-702-714-7001Extn: 9007

Social & Political Science Journals

Steve Harry

[email protected]

1-702-714-7001Extn: 9042

 
© 2008- 2018 OMICS International - Open Access Publisher. Best viewed in Mozilla Firefox | Google Chrome | Above IE 7.0 version
Leave Your Message 24x7