Stimulation of Thermogenesis via Beta-Adrenergic and Thyroid Hormone Receptors Agonists in Obesity Treatment Ã¢ÂÂ Possible Reasons for Therapy ResistanceAlina Kurylowicz1,2*
- *Corresponding Author:
- Alina Kurylowicz
Department of Human Epigenetics
Mossakowski Medical Research Centre
Polish Academy of Sciences 5 Pawinskiego
Street, 02-106 Warsaw, Poland
Tel: +48 22 6086591
E-mail: [email protected]
Received date: March 03, 2015; Accepted date: March 24, 2015; Published date: March 30, 2015
Citation: Kurylowicz A (2015) Stimulation of Thermogenesis via Beta-Adrenergic and Thyroid Hormone Receptors Agonists in Obesity Treatment – Possible Reasons for Therapy Resistance. J Pharmacogenomics Pharmacoproteomics 6:145. doi: 10.4172/2153-0645.1000145
Copyright: © 2015 Kurylowicz A. This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.
The worldwide epidemic of obesity and the limited effectiveness of the available treatments led to a renewed interest in developing therapeutic approaches which would reduce obesity by increasing energy expenditure. Knowledge of the mechanism involved in the regulation of thermogenesis in mammals has led to the belief that compounds activating adrenergic receptors beta and/or thyroid hormone receptors may be effective in obesity treatment. However, the translation of the results obtained in the in vitro and in animal studies on humans occurred to be not as direct and effective as expected. This mini-review discusses the potential role of thermogenesis impairment in development of human obesity as well as possible limitations in the application of thermogenic compounds in obesity treatment.