Stimuli-Responsive Hydrogels Bearing ÃÂ±amino acid Residues: a Potential Platform for Future Therapies
- *Corresponding Author:
- Mario Casolaro
Department of Biotechnology
Chemistry and Pharmacy, via Aldo Moro 2
University of Siena, 53100-Siena, Italy
E-mail: [email protected]
Received date: March 26, 2016; Accepted date: May 20, 2016; Published date: May 28, 2016
Citation: Mario Casolaro, Ilaria Casolaro (2016) Stimuli-Responsive Hydrogels Bearing amino acid Residues: a Potential Platform for Future Therapies. J Biomed Eng Med Devic 1: 111.
Copyright: © 2016 Casolaro M, et al. This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.
Vinyl hydrogels bearing α-aminoacid residues have been explored as platforms for the treatment of cancer, glaucoma and mood disorder therapies. Ionic/ionizable groups of the L-valine, L-phenylalanine and L-histidine residues are able to modify the swelling properties of the hydrogel on the basis of their thermodynamic characteristics. Greater basicity constants of functional groups improve a greater loading of the drug and a longer sustained-release pattern. The pH and the temperature affect the swelling of the hydrogel and increase ‘on demand’ the drug availability. A further stimulus based on alternating magnetic fields can be applied on hydrogels containing embedded magnetic nanoparticles used for site-specific controlled drug delivery. The diffusion process for the in vitro release of the drug (cisplatin, doxorubicin, pilocarpine, trazodone, citalopram and paroxetine) from the drugloaded hydrogels is mainly controlled by the drug-polymer interaction, that in the meanwhile preservs it’s bioactivity. The different interaction strength between the drug and the polymer may be a strategy to develop suitable capsules for long-term therapies.