alexa Stress Degradation Studies of Irbesartan and Hydrochlor
e-ISSN: 2347-7857 p-ISSN: 2347-7849

Research & Reviews: Journal of Pharmaceutics and Nanotechnology
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Research Article

Stress Degradation Studies of Irbesartan and Hydrochlorothiazide and Development of Validated Stability Indicating Method

Moin Shakeb1*, SB Puranik2 and Swamy Sreenivasa3

1Research Scholar, & Research Guide Bundelkhand University, Jhansi, Madhya Pradesh, India

2Research Scholar, & Research Guide Bundelkhand University, Jhansi, Madhya Pradesh, India

3Prof. C. N. Rao Center for Advanced Materials, Department of Chemistry, Tumkur University, Tumkur-572 103, Karnataka, India

*Corresponding Author:
Moin Shakeb
Research Scholar, & Research Guide Bundelkhand University, Jhansi, Madhya Pradesh, India

Received date: 18/08/2014; Revised date: 12/09/2014; Accepted date: 16/09/2014

 

Abstract

Irbesartan and Hydrochlorothiazide were subjected to different ICH prescribed stress conditions like acidic, alkaline, oxidation, reduction, thermal and photo stability condition and found that degraded peaks did not interfere with the peaks of drug under the study. A HPLC system LC Shimadzu UFLC-2000 Prominance LC- 20AD Binary Gradient System. SPDM 20A detector with Rheodyne injector and EnableC18 G column 250x 4.6mm, 5μm. Injection volume of 20μL was injected and eluted with the mobile phase consists of a mixture of 50mM Ammonium acetate: Acetonitrile (70:30% v/v) effluent was monitored at 235 nm using PDA detector. The method was linear over the concentration range of 150-350μg/ml (r2 = 0.999) with a limit of detection and quantitation of 0.019 and 0.053μg /ml for Irbesartan, and range of 15-35μg/ml (r2 = 0.999) with a limit of detection and quantitation of 0.023 and 0.070μg/ml for Hydrochlorothiazide The method was validated for linearity, range, precision, accuracy, specificity, selectivity and intermediate precision.

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