alexa Stress of Five Heavy Metals on the Resistance of Isolat
ISSN: 2157-7587

Hydrology: Current Research
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Research Article

Stress of Five Heavy Metals on the Resistance of Isolates from Swine Wastewater to Four Antibiotics

Yanbin Xu1,2*, Jingjing Ruan2, Maoyu Hou2, Xinxin Zhao2, Li Zheng2, Shaoqi Zhou1 and Baohong Yuan3
1College of environmental science and engineering, South China University of Technology, Guangzhou 510008, China
2School of environmental science and engineering, Guangdong University of Technology, Guangzhou 510006, China
3School of Basic Courses, Guangdong Pharmaceutical University, Guangzhou 510006, China
Corresponding Author : Yanbin Xu
Department of environmental science and engineering
South China University of Technology, Guangzhou 510008, China
Tel: +8613660621925
E-mail: [email protected]
Received May 31, 2014; Accepted June 19, 2014; Published June 30, 2014
Citation: Xu YB, Ruan JJ, Hou MY, Zhao XX, Zheng L, et al. (2014) Stress of Five Heavy Metals on the Resistance of Isolates from Swine Wastewater to Four Antibiotics. Hydrol Current Res 5:173. doi: 10.4172/2157-7587.1000173
Copyright: © 2014 Xu YB, et al. This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.
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Co-existence of heavy metals and antibiotics becomes increasingly common in environmental pollution.
To investigate the stress of heavy metals on microbial resistance to antibiotics, fifty-six strains of bacteria were initially isolated from some swine water in Guangzhou city, based on their resistance to four antibiotics (cefradine, norfloxacin, amoxicillin, tetracycline) and five heavy metals (Pb2+, Cr(VI), Hg2+, Cu2+, Zn2+), a gram-negative isolate, Pseudomonas putida XX6, was selected to study the detail stress rules of heavy metals on its resistance to antibiotics. The antibiotics incidences of these isolates were in the order of norfloxacin>amoxicillin>cefradine>tetracycline, and that of P. putida XX6 was  cefradine>amoxicillin≈tetracycline>norfloxacin. The addition of heavy metals made all isolates’  resistance to antibiotics decrease, and Cr(VI) impacted their resistance to norfloxacin most obviously. If
the concentration of heavy metals was the most important factor affecting the resistance of P. putida XX6 to the antibiotics? There was a positive correlation between the bacterial resistances to antibiotics and heavy metals of low concentrations, and the correlation turned to negative with the concentrations of heavy metals increasing. But the bacterial resistance to amoxicillin or cefradine remained irrelevant to the concentrations of Cr (VI) or Pb2+. Results showed that the combined effect of antibiotics and heavy metals could alter their individual effect on bio-toxicity as well as on the biological removal capability of pollutants.


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