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Stress Response to Surgery, Anesthetics Role and Impact on Cognition | OMICS International | Abstract
ISSN: 2155-6148

Journal of Anesthesia & Clinical Research
Open Access

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Review Article

Stress Response to Surgery, Anesthetics Role and Impact on Cognition

Aceto Paola1*, Lai Carlo2, Dello Russo Cinzia3, Perilli Valter1, Navarra Pierluigi3 and Sollazzi Liliana1

1Department of Anesthesiology and Intensive Care, Agostino Gemelli Hospital, Rome, Italy

2Department of Dynamic and Clinical Psychology, University of Rome “Sapienza”, Rome, Italy

3Department of Pharmacology, Catholic University of Sacred Heart, Rome, Italy

*Corresponding Author:
Paola Aceto
Department of Anaesthesiology and Intensive Care
Catholic University of Sacred Heart
Largo A. Gemelli, 8-00168, Rome, Italy
Tel: +39-06-30154507
Fax: +39-06-3013450
E-mail: [email protected], [email protected]

Received date: June 08, 2015 Accepted date: July 08, 2015 Published date: July 13, 2015

Citation: Paola A, Carlo L, Cinzia DR, Valter P, Pierluigi N, et al. (2015) Stress Response to Surgery, Anesthetics Role and Impact on Cognition. J Anesth Clin Res 6:539. doi: 10.4172/2155-6148.1000539

Copyright: © 2015 Paola A, et al. This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.


The stress response to surgery includes a number of hormonal changes initiated by neuronal activation of the Hypothalamo-Pituitary-Adrenal (HPA) axis. Surgery is one of the most potent activators of ACTH and cortisol secretion, and increased plasma concentrations of both hormones can be measured few minutes after the start of surgery. A variable inhibition of ACTH-stimulated production of cortisol by anesthetic drugs has been demonstrated in clinical studies. Endocrine response to stress also includes a release of pituitary hormone prolactin which is poorly affected by anesthesia. These two hormones seem to mostly contribute to memory consolidation processes during anesthesia. This review summarizes the main aspects of interaction between stress response to surgery and cognition during general anesthesia.