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ISSN: 2155-6148

Journal of Anesthesia & Clinical Research
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Research Article

Stress Response to Total Abdominal Hysterectomy under General Anesthesia in Type 2 Diabetic Subjects

Kawsar Sardar1*, Hafizur Rahman M2 , Abdur Rashid M2 , Omar Faruque M2 , Liaquat Ali2 , Shahera Khatun UH3 and Mesbahuddin Iqbal K4

1Dept Anesthesiology, BIRDEM Hospital and Ibrahim Medical College, Dhaka, Bangladesh

2Dept of Biochemistry and Cell Biology, BIRDEM, Dhaka, Bangladesh

3Dept of Anesthesiology and Intensive Care Medicine, Dhaka Medical College, Dhaka, Bangladesh

4Chief Consultant, Dept Anesthesiology, Apollo Hospital, Dhaka, Bangladesh

*Corresponding Author:
Kawsar Sardar
Associate Professor and Pain specialist
Department of Anesthesiology
BIRDEM General Hospital and Ibrahim Medical College
Sahbag, Dhaka, Bangladesh
E-mail: [email protected]

Received date: May 29, 2013; Accepted date: June 24, 2013; Published date: June 26, 2013

Citation: Sardar K, Hafizur Rahman M, Abdur Rashid M, Omar Faruque M, Liaquat Ali, et al. (2013) Stress Response to Total Abdominal Hysterectomy under General Anesthesia in Type 2 Diabetic Subjects. J Anesthe Clinic Res 4:329. doi: 10.4172/2155-6148.1000329

Copyright: © 2013 Sardar K, et al. This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.

Abstract

Aims: This study was designed to investigate the hemodynamic alteration and changes of glycemic, cortisol and electrolytes status in total abdominal hysterectomy of type 2 diabetic subjects under general anesthesia.

Subjects and method: Fourty subjects under general anesthesia for total abdominal hysterectomy were recruited and thrice blood samples were collected from each subject, before anesthesia (PT0), 10 minutes after incision (PT1) and 10 minutes after extubation (PT2). Plasma glucose was measured by glucose-oxidase method, serum C-peptide and serum cortisol by chemiluminescence’s based ELISA technique (Immulite, USA). Serum electrolytes were measured by Dry Chemistry method (DT-60, USA)

Results: All the subjects were hemodynamically stable during surgery. Plasma glucose increased significantly in PT2. Serum cortisol was significantly higher in PT1 and PT2 than PT0.

Conclusions: Total abdominal hysterectomy under general anesthesia in well controlled type 2 diabetic subjects is accompanied by a hyperglycemic response which results from rise of insulin antagonists like cortisol.

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