Stress-Related Weight Gain: Mechanisms Involving Feeding Behavior, Metabolism, Gut Microbiota and InflammationDemori Ilaria1,2,* and Grasselli Elena1,3
- *Corresponding Author:
- Demori I
Dipartimento di Scienze della
Terra dell’Ambiente e della Vita
Università di Genova, Italy
E-mail: [email protected]
Received date: December 19, 2015 Accepted date: January 11, 2016 Published date: January 18, 2016
Citation:Demori I, Grasselli E (2016) Stress-Related Weight Gain: Mechanisms Involving Feeding Behavior, Metabolism, Gut Microbiota and Inflammation. J Nutr Food Sci 6:457. doi: 10.4172/2155-9600.1000457
Copyright: © 2016 Demori I,, et al. This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.
The body stress response is a highly adaptive phenomenon activated by different types of physical and emotional stressors. Chronic and/or excessive stress is, on the other hand, often maladaptive. In this short review we deal with the influence of the stress response on weight gain and fat accumulation. Chronic stress appears to promote a shift from homeostatic regulation of food intake to hedonic overeating. Hyper activation of the stress response triggers metabolic changes that might slow down energy expenditure while promoting visceral fat accumulation. Chronically elevated glucocorticoid levels also enhance the inflammatory response and cytokines secreted by visceral fat can in turn increase metabolic abnormalities towards obesity. Changes in the gut microbiota, which is highly sensitive to the stress hormones as well as to the type of food ingested, can also be involved in stress-related weight gain. Given the vicious circles that interlock stress, food, metabolism and inflammation, strategies for stress control and management should be taken into account to prevent weight gain particularly in Western-lifestyle countries.