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Stroke Patients after repetitive Transcranial Magnetic Stimulation (rTMS) - Alterations of Tryptophan Metabolites in the Serum | OMICS International | Abstract
ISSN: 2376-0281

International Journal of Neurorehabilitation
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Research Article

Stroke Patients after repetitive Transcranial Magnetic Stimulation (rTMS) - Alterations of Tryptophan Metabolites in the Serum

Berthold Kepplinger1,2,3, Brenda Sedlnitzky-Semler1,4, Sabine Eigner2, Pavol Kalina2, Petra Berger2 and Halina Baran1,4*

1Karl Landsteiner Research Institute for Neurochemistry, Neuropharmacology, Neurorehabilitation and Pain Therapy, Mauer, Austria

2Neurological Division, Landesklinikum Mauer, Austria

3Neurologisches Rehabilitations Zentrum, Kittsee, Austria

4Department of Biochemical Sciences, Veterinary Medical University Vienna, Austria

*Corresponding Author:
Halina Baran
Professor of Neurochemistry, Neurochemical laboratory
Karl Landsteiner Research Institute for Neurochemistry
Neuropharmacology, Neurorehabilitation and Pain Treatment Mauer
Neuropsychiatric Hospital, Landesklinikum, Lower Austria
3360 Mauer-Amstetten, Austria
Tel: 0043 7475 9004
E-mail: [email protected]

Received date: June 24, 2014; Accepted date: October 31, 2014; Published date: November 15, 2014

Citation: Kepplinger B, Sedlnitzky-Semler B, Eigner S, Kalina P, Berger P, et al (2014) Stroke Patients after repetitive Transcranial Magnetic Stimulation (rTMS)–Alterations of Tryptophan Metabolites in the Serum. Int J Neurorehabilitation 1:128. doi:10.4172/2376-0281.1000128

Copyright: © 2014 Kepplinger B et al. This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.


Repetitive transcranial magnetic stimulation (rTMS) as a new non-invasive painless procedure has been tested for augmentation of motor performance and reduction of spasticity in post-stroke patients. Stroke patients (N = 34) were recruited for rTMS treatment and brain activity analysis (EEG) was performed before and after rTMS. The effect of rTMS was evaluated using National Institute of Health Stroke Scale (NIHSS), Barthel – Index and Ashworth Scale. The content of L-tryptophan (L-TRP), L-kynurenine (L-KYN), kynurenic acid (KYNA) and anthranilic acid (ANA) was determined in the serum of stroke patients before the 1st, after the 5th and after 10th rTMS application using high performance liquid chromatography. In a separate experiment, L-TRP metabolites were determined in the serum of an independent group of stroke patients (N=47) and control subjects (N=6). The content of L-TRP and L-TRP metabolites in the serum of stroke patients was significantly increased, L-TRY was 121% of CO; L-KYN 161% of CO, p<0.015; ANA 280 % of CO, p<0.001; KYNA 243% of CO, p<0.001, compared to control subjects. Similar changes were found in stroke patients recruited for rTMS. After the 10th rTMS treatment L-KYN and ANA levels increased moderately but significantly in the serum and it was L-KYN 107%, p<0.01; ANA 110%, p=0.055, versus the value before 1st rTMS, respectively. The ratios L-KYN/TRP and ANA/KYNA increased moderately but significantly after the 10th rTMS. Creatin kinase and prolactin levels were in normal range during rTMS. Stroke patients treated with rTMS have shown a significant enhancement of motor performance and moderate reduction of spasticity. The alteration of ANA/KYNA ratio after rTMS might be of significance with respect to the clinical improvement of patients. The present study gives favour for rTMS as a means for neurorehabilitation of patients after stroke. Notable, the management of therapies following rTMS are of importance for an improvement of hand and fingers activities, as observed within this study.


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