Structural, Magnetic and In Vitro Bioactivity of Co-Cu Ferrite and Bioglass Composite for Hyperthermia in Bone Tissue Engineering
Sampath KA, Himanshu T, Kevin B and Singh SP*
Department of Ceramic Engineering, Indian Institute of Technology (Banaras Hindu University), Varanasi, India
- Corresponding Author:
- Singh SP
Department of Ceramic Engineering
Indian Institute of Technology
(Banaras Hindu University), Varanasi221005, India
Tel: 0542 236 8106
E-mail: [email protected]
Received date: December 03, 2015; Accepted date: January 28, 2016; Published date: February 04, 2016
Citation: Sampath KA, Himanshu T, Kevin B, Singh SP (2016) Structural, Magnetic and In Vitro Bioactivity of Co-Cu Ferrite and Bioglass Composite for Hyperthermia in Bone Tissue Engineering. Bioceram Dev Appl 6:091. doi:10.4172/2090-5025.1000091
Copyright: © 2016 Sampath KA, et al. This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.
Magnetic induction hyperthermia is emerging for cancer treatment with bioceramic materials rather radiotherapy and chemotherapy. Copper substituted cobalt ferrites as Co1-xCuxFe2O4 (where x=0.2, 0.4, 0.6, 0.8) ware prepared through self-propagating high-temperature synthesis (SHS) and the effect of copper on the structural, magnetic and biological properties was investigated. XRD revealed the formation of solid solution and the magnetic measurements showed the formation of soft ferrites as compared to CoFe2O4. The bioactive composite was prepared by incorporating the ferrite having optimum magnetic properties with bioactive glass and the constituent phases in the sintered composite were analyzed by X-ray diffraction (XRD). The bioactive composite comprised of Na2Ca2Si3O9 phase in solid solution. In vitro bioactivity of the composite was investigated in simulated body fluid (SBF) under physiological conditions. The precipitated hydroxy carbonated apatite (HCA) layer was confirmed by Fourier Transform Infra-Red spectrometer (FTIR), scanning electron microscopy (SEM) and XRD techniques. Cell viability and cytotoxicity against osteoblast MG63cell lines exhibit that the composite is cytocompatible.