alexa Struma Ovarii Associated with Pseudo-Meigs' Syndrome and Elevated Serum CA 125: A Case Report and Literature Review
ISSN: 2161-0932

Gynecology & Obstetrics
Open Access

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Case Report

Struma Ovarii Associated with Pseudo-Meigs' Syndrome and Elevated Serum CA 125: A Case Report and Literature Review

Rawan Obeidat*, Timothy J Perren and Samir A Saidi

Department of Gynecological Oncology, St James’s University Hospital, Leeds, UK

Corresponding Author:
Rawan Obeidat
Department of Gynaecological Oncology
Level 4 Bexley Wing, St James’s University Hospital
Beckett street, Leeds, UK LS9 7TF
Tel: +44 7787745496
E-mail: [email protected]

Received Date: July 16, 2012; Accepted Date: August 27, 2012; Published Date: August 29, 2012

Citation: Obeidat R, Perren TJ, Saidi SA (2012) Struma Ovarii Associated with Pseudo-Meigs’ Syndrome and Elevated Serum CA 125: A Case Report and Literature Review. Gynecol Obstet 2:129. doi: 10.4172/2161-0932.1000129

Copyright: © 2012 Obeidat R, et al. This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.



The association of struma ovarii with Pseudo-Meigs’ syndrome and elevation of CA 125 has been reported in literature. Here we report a 55-year-old with benign struma ovarii who presented with ascites, small left pleural effusion, suspicious left ovarian mass and elevated serum CA 125 level. Repeated cytology tests were negative for malignancy. The radiologic appearance was highly suggestive of an ovarian malignancy and due to her overall state of illness the patient received 3 cycles of chemotherapy. Chemotherapy had no impact on the rate of accumulation of ascites, CA 125 level or the size of the ovarian mass highlighting the need to reconsider the initial diagnosis. Diagnostic left oophorectomy revealed struma ovarii and was followed by resolution of the ascites and normalization of the serum CA 125. No recurrence of the ascites or of the tumor has been observed during the 5 months follow-up. Struma ovarii or other dermoid variants should be considered in the differential diagnosis in patients with ascites, pleural effusions and elevated CA125 level but with negative cytology. Diagnostic laparoscopic oophorectomy should also be considered within the standard protocol for diagnosis of indeterminate adnexal masses.


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