alexa Studies of Acute and Chronic Toxicity of Commercial Her
ISSN: 2161-0525

Journal of Environmental & Analytical Toxicology
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Research Article

Studies of Acute and Chronic Toxicity of Commercial Herbicides with Glyphosate against Danio rerio

Jofré DM1, Alvarez M1, Perez E2, Mohamed F2, Jerez MB3, Juri Ayub M3, Enriz RD1 and Giannini FA1*
1Área de Química General e Inorgánica. Facultad de Química, Bioquímica y Farmacia, Universidad Nacional de San Luis, San Luis – Argentina. Chacabuco y Pedernera, (5700) San Luis, Argentina
2Área de Morfología, Laboratorio de Histología. Facultad de Química, Bioquímica y Farmacia. Universidad Nacional de San Luis- Av. Ejército de los Andes 950, Bloque I 1°piso (5700) San Luis, Argentina
3IMIBIO-SL CONICET, Facultad de Química, Bioquímica y Farmacia, Universidad Nacional de San Luis, Ejercito de los Andes 950, San Luis (5700), Argentina
Corresponding Author : Giannini FA
Área de Química General e Inorgánica.
Facultad de Química, Bioquímica y Farmacia
Universidad Nacional de San Luis
San Luis – Argentina. Chacabuco y Pedernera
(5700) San Luis, Argentina
Tel: 0266-4430515
E-mail: [email protected]
Received November 16, 2015; Accepted December 09, 2015; Published December 12, 2015
Citation: Jofré DM, Alvarez M, Perez E, Mohamed F, Jerez MB, et al. (2016) Studies of Acute and Chronic Toxicity of Commercial Herbicides with Glyphosate against Danio rerio. J Environ Anal Toxicol 6:340. doi:10.4172/2161-0525.1000340
Copyright: © 2016 Jofré DM, et al. This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.
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Abstract

Glyphosate or N-(phosphonomethyl) glycine is a broad spectrum non-selective systemic herbicide, used to kill weeds, mainly in soybean crops. Nowadays there are many controversies about the intensive use of these herbicides due to the potential environmental impact and the effects on human health. The environmental impacts of commercial Glyphosate formulation Roundup were assessed by evaluation of acute and chronic toxicity of Danio rerio fish. The effects of glyphosate commercial formulations and glyphosate isopropylamine salt solutions were evaluated in different steps. First the lethal doses of Roundup herbicide toward the experimental models were determined. Subsequently the specie was exposed to sublethal concentrations of both, the commercial preparations and pure glyphosate salt in order to evaluate the chronic toxicity. Acute toxicity was assessed by calculating the mortality indexes and chronic toxicity by measuring several biochemical parameters such as the activity of marker enzymes like aspartate aminotransferase (AST), alanine aminotransferase (ALT) and acetylcholinesterase (AchE). The registers of histological alterations in liver tissue sections were also considered in this study. Commercial herbicides produce mortality of D. rerio and sublethal doses of these herbicides and the salt of the pure compound produce effects of chronic toxicity at the liver and muscle level; such are enough causes to limit the potential survival of these organisms in the medium.

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