Study of Attenuation of Cardiovascular Response during Laryngoscopy and Intubation Using Two Different Doses of Pregabalin as Premedication in Controlled Hypertensive Patients- A RCT
Rajesh Meena*, Kavita Meena and Shashi Prakash
Institute of Medical Sciences, Banaras Hindu University, Varanasi, Uttar Pradesh, India
- *Corresponding Author:
- Rajesh Meena
Institute of Medical Sciences
Banaras Hindu University, Varanasi, Uttar Pradesh, India
E-mail: [email protected] gmail.com
Received date: January 11, 2016; Accepted date: Feburary 17, 2016; Published date: Feburary 27, 2016
Citation: Meena R, Meena K, Prakash S (2016) Study of Attenuation of Cardiovascular Response during Laryngoscopy and Intubation Using Two Different Doses of Pregabalin as Premedication in Controlled Hypertensive Patients-A RCT. J Anesth Clin Res 7:607. doi: 10.4172/2155-6148.1000607
Copyright: © 2016 Meena R, et al. This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.
Introduction: laryngoscopy and tracheal intubation are powerful noxious stimuli that should be attenuated.1 effect more severe in hypertensive patients.2 The present study evaluated the safe and clinically effective dose of oral pregabalin as premedication for attenuation of pressor response of airway instrumentation in controlled hypertensive patients.
Methods: After ethical committee clearance total of 90 controlled hypertensive adult consented patients aged 30-60 years(M/F),ASA grade II were included,and randomized into three groups of 30 patients each by computer generated random number tables. Group I received oral placebo, Group II oral pregabalin 75 mg HS+150 mg 1 h before surgery and Group III oral pregabalin 75 mg HS+300 mg 1 h prior to induction. Duration of study 2012-2013. Data was analysed using Chi-square, Anova and T test and statistical analysis was performed using SPSS, windows version 19.0. the power of the study from primary object is 80 %. Anaesthetic technique was standardized and all groups were assessed for preÃ¢ÂÂoperative sedation, haemodynamic changes after the premedication, before and after induction, after laryngoscopy and intubation.
Results: PreÃ¢ÂÂoperative sedation levels were higher with pregabalin premedication. Significant increase in heart rate and mean arterial pressure was observed in Groups I and II after airway instrumentation, while statistically significant attenuation of mean arterial pressure was seen in Group III. No significant decrease in heart rate was observed in any group.
Conclusion: Oral pregabalin as premedication adequately sedated the patients, attenuated haemodynamic pressor response in a doseÃ¢ÂÂrelated fashion.