alexa Study of In vitro Bioactivity and Biodegradability of the Hydrothermally Prepared Carbon Nanofibrous/Hydroxyapatite (Cnf/Ha) Membranes.
ISSN: 2572-4916

Journal of Bone Research
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Research Article

Study of In vitro Bioactivity and Biodegradability of the Hydrothermally Prepared Carbon Nanofibrous/Hydroxyapatite (Cnf/Ha) Membranes.

Abd El-Aziz A1,2*, Azza El-Maghraby1 and Sherif H Kandil2

1Department of Fabrication Technology, Advanced technology and New Materials Research Institute, Alexandria University, Egypt

2Department of Materials Science, Institute of Graduate Studies and Research, Alexandria University, Egypt

*Corresponding Author:
Abd El-Aziz A
Department of Fabrication Technology and Department of Materials Science
Alexandria University, Egypt
Tel: 01149431552
E-mail: [email protected]

Received date: June 09, 2017; Accepted date: July 05, 2017; Published date: July 11, 2017

Citation: Abd El-Aziz A, El-Maghraby A, Kandil SH (2017) Study of In vitro Bioactivity and Biodegradability of the Hydrothermally Prepared Carbon Nanofibrous/ Hydroxyapatite (Cnf/Ha) Membranes. J Bone Res 5:176. doi: 10.4172/2572-4916.1000176

Copyright: © 2017 Abd El-Aziz A, et al. This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.



Critical size bone defects are orthopedic defects that will not heal without intervention or that will not completely heal over the natural life time of the animal. Although bone generally has the ability to regenerate completely however, critical defects need sort of scaffold to do so. In the current study, we proposed a method to get a Carbon NanoFibrous (CNFs) / Hydroxyapatite (HA) bioactive scaffold. The CNF nonwoven fabrics were obtained by the use of the electrospinning process of the polymeric solution of Poly Acrylonitrile (PAN) and next thermal treatment of both stabilization and carbonization processes, then the CNFs membranes were functionalized by (6.8 wt.%) HA by the hydrothermal process (130ºC for 90 min). The prepared membranes were in-vitro tested for bioactivity in Simulated Body Fluid (SBF) solution and for biodegradability in Phosphate Buffer Saline (PBS) solution. We have successfully prepared a bioactive and biodegradable membrane by immersing it in SBF and PBS solutions respectively for 14 days, where a bioactive layer of Hydroxy-Carbonated Apatite (HCA) was found on its surface. The formed layer of HCA has been characterized by XRD, FTIR, and SEM. The biodegradability of the membranes has been characterized by FTIR, SEM, and ICP for the PBS solution after different time intervals (1, 3, 5, 7 and 14) days. The membrane of (CNF/6%HA) is more biodegradable than other membranes of (CNF, and CNF/8%HA).


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