alexa Study of Oral Acute Toxicity/Pathogenicity of the Tsuka
ISSN: 2167-1052

Advances in Pharmacoepidemiology and Drug Safety
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Research Article

Study of Oral Acute Toxicity/Pathogenicity of the Tsukamurella Paurometabola Active Agent of the Biological Nematicide C-924 (Hebernem®)

Lizet Aldana Velazco1*, Dania Bacardí Fernández1, Odette Beiro Castro2, Dra. Karelia Cosme1, Lic. Yamilka Ramírez Núñez3, Carmen Valenzuela Silva1, Nelson Merino García4, Juan Fco. Sánchez de la Morena2, Lic Lorelys Milá Cáceres1, Téc. Rubén Amaya Izquierdo1, Téc. José Suárez Alba1, Onelio Carballo2, Jesús Mena Campos3 and Carlos Borroto1
1Centro de Ingeniería Genética y Biotecnología (CIGB), Ave 31 % 158 y 190, Cubanacán, Playa Habana, Cuba
2Centro Nacional de Toxicología (CENATOX), Habana, Cuba, Ave 31 y 114. Marianao, CP. 14020, Ciudad de la Habana, Cuba
3Centro de Ingeniería Genética y Biotecnología de Camaguey (CIGB-Cam.), Cuba. Circunvalación Norte y Avenida Finlay. Camaguey 70100. Cuba
4Centro de Investigaciones y Desarrollo de medicamentos, Habana, Cuba
*Corresponding Author : Lizet Aldana Velazco
Centro de Ingeniería Genética y Biotecnología (CIGB)
Ave 31 % 158 y 190, Cubanacán, Playa Habana, Cuba
Tel: (537) 2504306
Fax: (53-7) 2718070
E-mail: [email protected]
Received December 07, 2011; Accepted February 08, 2012; Published February 21, 2012
Citation: Velazco LA, Fernández DB, Castro OB, Cosme DK, Núñez LYR, et al. (2012) Study of Oral Acute Toxicity/Pathogenicity of the Tsukamurella paurometabola Active Agent of the Biological Nematicide C-924 (Hebernem®). Adv Pharmacoepidem Drug Safety 1:106. doi:10.4172/2167-1052.1000106
Copyright: © 2012 Velazco LA et al. This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.


The nematodes constitute one of the most phyto-pathogenic species in agriculture, using chemical and biological control agents. The Tsukamurella paurometabola is a bacterial strain with possibilities of being used as a nematicide; thus, it is necessary to evaluate the effect of its administration in lab animals with the objective of estimating its toxicity, infectivity and pathogenicity. To accomplish this aim, it was administered a single dose of 108 ufc/animal with T. paurometabola C-924 in three variants as an active agent, final product (HEBERNEM®) and inactive final product by oral route to Sprague-Dawley rats of both sexes, and their respective placebos. The analyzed variables were: clinical observation, feed and water consumption, body weight, infectivity (tissues, organs and biological fluids), clearing or persistence (faeces collection) and gross and microscopic evaluations of interest organs. The obtained results showed that the administration of this microorganism in their three variants and their placebos, under our experimental conditions, didn’t cause lethality neither influenced on weight, behavior and the physical state in the experimentation animals. The persistence showed that the microorganism was totally eliminated towards the day 15 of the study; likewise the infectivity determinations demonstrated the non-existence of colony formed units of the T. paurometabola in different times of samplings, resulting its inability to invade the guest’s natural barriers, to infect it or to cause pathogenicity. The administration of the T. paurometabola, as an active agent and as final product, didn’t cause signs, infective or pathogenic or toxic reactions in the experimentation animals.


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