alexa Study on the Features of Coronary Artery Atheromatous P
ISSN: 2329-6607

Cardiovascular Pharmacology: Open Access
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Research Article

Study on the Features of Coronary Artery Atheromatous Plaque for Patients with Impaired Glucose Tolerance when Applying Intravascular Ultrasound

Jinming Cen1, Qingyuan Xiong2, Xilin Yang1* and Zhaoyan Xu1

1The Cardiology Department of the 1st People Hospital of Foshan, China

2Department of Clinical Laboratory, The Chancheng District Central Hospital of Foshan, China

Corresponding Author:
Xilin Yang
The Cardiology Department of the 1st People Hospital of Foshan
Guangdong 528000, China
Tel: 0757-8316 3155
E-mail: [email protected]

Received date: February 23, 2016; Accepted date: March 08, 2016; Published date: March 14, 2016

Citation: Cen J, Xiong Q, Yang X, Xu Z (2016) Study on the Features of Coronary Artery Atheromatous Plaque for Patients with Impaired Glucose Tolerance when Applying Intravascular Ultrasound. Cardiovasc Pharm Open Access 5:177. doi:10.4172/2329-6607.1000177

Copyright: © 2016 Cen J, et al. This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.

 

Abstract

Objective: By applying Intravascular Ultrasound (IVUS) to patients with mild-to-moderate coronary stenosis defined by Coronary Angiography (CAG), it is analyzed on the features of coronary artery atheromatous plaque for patients with impaired glucose tolerance and discussed about the clinical significance as well as the relationship between HbA1c levels and coronary artery lesion. Methods: HbA1c testing was applied to 85 patients (a total of 96 lesions) with 46 cases in Group of Impaired Glucose Tolerance (IGT Group) and 39 cases in Group of Normal Blood Glucose (NBG Group). IVUS was applied to qualitatively and quantitatively analyse the lesion vessel of both groups. Measurement was done both to target lesion for data of External Elastic Membrane Area (EEMA), Minimal Lumen Area (MLA), Plaque Area (PA), Plaque Burden (PB), and to the reference segments for data of Reference External Elastic Membrane Area (REEMA), Minimal Lumen Area (RMLA), Plaque Area (RPA), Plaque Burden (RPB). Results: The level of HbA1c in IGT Group was significantly higher than that in NBG Group (P < 0.05). For IGT Group, there were more soft plaque, eccentric plaque, positive remodeling and less calcification while for NBG Group, there were more performance for the hard plaque, calcification, no reconstruction and negative remodeling (P < 0.05). For IGT Group, MLA was less than NBG Group while EEMA, PA and PB were obviously higher than NBG Group (P < 0.05). In the meantime, RMAL was clearly less than NBG Group while RPA and RPB were higher than NBG Group (P < 0.05). HbA1c levels was positively correlated with PA, PB, but negatively correlated with MLA. Conclusion: IVUS shows a higher value to the evaluation of mild-to-moderate coronary lesions. The coronary artery lesions of IGT Group were more serious and widespread than that of NBG Group, and the level of HbA1c might provide some value for the judgment of the severity of coronary artery lesion.

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