Study the Small and Dense Lipoprotein Levels (LDLsd) in Coronary Artery Disease
|Agustin Nestor Joison1*, Sergio Rufino1 and Enrique Majul2|
|1Associate Professor of Medical Chemistry III, Faculty of Medicine, UCC, Argentina|
|2Chairman of Medical Chemistry III, Faculty of Medicine, UCC, Argentina|
|Corresponding Author :||Agustin Nestor Joison
Associate Professor of Medical Chemistry III
Faculty of Medicine, UCC, Dean Funes 1752 Tower
I Floor 9 dep C, 5003 Córdoba, Argentina
E-mail: [email protected]
|Received February 03, 2014; Accepted April 16, 2014; Published April 22, 2014|
|Citation: Joison AN, Rufino S, Majul E (2014) Study the Small and Dense Lipoprotein Levels (LDLsd) in Coronary Artery Disease. J Cardiovasc Dis Diagn 2:151. doi: 10.4172/2329-9517.1000151|
|Copyright: © 2014 Joison AN, et al. This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.|
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Objective: To study the height LDLsd levels and coronary disease relation.
Methods: Experimental transversal and retrospective study of sample not probabilistic random. 62 individuals were studied of both sex who did attended a consultation specialized in cardiology at the University Queen Fabiola Clinic of Cordoba city Argentina. The LDLsd are separated using vertical polyacrylamide gradient gel electrophoresis to 3% in non-reducing conditions. The presence of LDLsd was established when identified in the serum LDLsd abnormal band with Rf>0.36.
Results: 26 patients have LDLsd elevated and 36 patients with normal LDLsd Rf<0.36). In 36 (58%) patients with normal LDLsd, 27 (75%) of them have not coronary disease and diabetes. A correlation study between factors of risk and coronary disease with a 95% of statically significance resulted that 16 patients with coronary disease had height LDLsd (Rf>0.36) and 7 patients without disease (p<0.001).
Conclusion: The research revealed high levels of LDLsd in subjects assessed, by association with coronary disease increased significantly. Patients with normal TGR who had elevated levels of LDLsd had developed coronary artery disease; it confirms to LDLsd as independent of coronary disease risk factor.