alexa Sub-Acute Oral Toxicity of Zinc Oxide Nanoparticles in Male Rats
ISSN: 2157-7439

Journal of Nanomedicine & Nanotechnology
Open Access

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Research Article

Sub-Acute Oral Toxicity of Zinc Oxide Nanoparticles in Male Rats

Imen Ben-Slama1, Salem Amara1*, Imen Mrad1, Naima Rihane1, Karim Omri2, Jaber EL Ghoul2, Lassaad EL Mir2,3, Khemais Ben Rhouma1, Hafedh Abdelmelek1 and Mohsen Sakly1

1Laboratoire de Physiologie Intégrée Faculté des Sciences de Bizerte, 7021 Jarzouna, Tunisia

2Laboratory of Physics of Materials and Nanomaterials Applied at Environment, College of Sciences in Gabes, Tunisia

3Al-Imam Mohammad Ibn Saud Islamic University, College of Sciences, Department of Physics, Riyadh, Saudi Arabia

*Corresponding Author:
Salem Amara
Laboratoire de Physiologie Intégrée
Faculté des Sciences de Bizerte
Jarzouna 7021, Tunisia
Tel: 0021652322418;
Fax: 0021672590566
E-mail: [email protected]

Received January 20, 2015; Accepted Date: March 27, 2015; Published Date: April 13, 2015

Citation: Ben-Slama I, Amara S, Mrad I, Rihane N, Omri K, et al. (2015) Sub-Acute Oral Toxicity of Zinc Oxide Nanoparticles in Male Rats. J Nanomed Nanotechnol 6:284. doi:10.4172/2157-7439.1000284

Copyright: © 2015 Ben-Slama I, et al. This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.



ZnO-NPs suspended in distilled water were administered to Wistar rats at dose of 10 mg/ kg body weight through oral gavage for 5 consecutive days. The mean body weight gain in rats given ZnO-NPs was similar to this of control group, so no significant differences in the relative organs weight were observed between the ZnO-NPs treated-rats and control. Moreover, ZnO-NPs-exposed rats showed normal values for the complete blood count test. However, biochemical assays showed that sub-acute exposure to ZnO-NPs induced a marked increase of aspartate aminotransferase (AST) and alanine aminotransferase (ALT). Therefore, uric acid, creatinine and glucose levels are not modulated by ZnONPs administration. These biochemical findings were supported by histopathology examination, which showed minor morphological changes in rat tissues. Sub-acute exposure to ZnO-NPs does not affect the exploratory behaviors and the anxious index of rats.


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