alexa Subcutaneous IgG Replacement Therapy by Push in 32 Pati
ISSN: 2161-1459

Journal of Clinical & Experimental Pharmacology
Open Access

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Research Article

Subcutaneous IgG Replacement Therapy by Push in 32 Patients with Primary Immunodeficiency Diseases in Argentine

Bezrodnik Liliana1*, Gómez Raccio Andrea1, Regairaz Lorena2, Díaz Ballve Damacia1, Seminario Gisela1, Moreira Ileana1 and Giovanni Daniela Di1

1Inmunología, Hospital de Niños “Dr. Ricardo Gutiérrez”, Bs. As. Argentina

2Inmunología, Hospital de Niños “Sor María Ludovica”, La Plata. Argentina

*Corresponding Author:
Liliana Bezrodnik
CABA, Argentina
Tel/Fax: 54 011 47859844
E-mail: [email protected]

Received Date: December 21, 2013; Accepted Date: January 17, 2014; Published Date: January 24, 2014

Citation: Liliana B, Andrea GR, Lorena R, Damacia DB, Gisela S, et al. (2014) Subcutaneous IgG Replacement Therapy by Push in 32 Patients with Primary Immunodeficiency Diseases in Argentine. Clin Exp Pharmacol 4:148. doi: 10.4172/2161-1459.1000148

Copyright: © 2014 Liliana B, et al. This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.

 

Abstract

Introduction: Regular replacement with immunoglobulin infusions is the mainstay of treatment in the majority of primary immunodeficiencies. Several studies showed that Subcutaneous Immunoglobulin (SCIG) has similar efficacy to Intravenous Immunoglobulin (IVIG) in preventing infections in PID patients. Here we report effectiveness, safety and tolerance of SCIG replacement therapy by push in 32 pediatric and adult patients with humoral PID in Argentina. Results: We describe 32 patients that received SCIG treatment between July 2011 and May 2012. 17 male and 15 female from 2 Immunology Centers; aged from 8 months to 40 years (median: 11 years). 30 patients previously received IVIG treatment. Among them, fifteen received 9 months of SCIG treatment administered by pump. The other 2 patients started the immunoglobulin replacement treatment directly with SCIG by push. The mean dose of SCIG was 133 mg/kg/week (range 100-192). The annual rate of any infection was 1, 2 infection/year/patient for subcutaneous treatment. The frequency of adverse effects was 0.02% with the SCIG. At the end of the study, all patients chose SCIG home-therapy regimen and referred much more comfort with SCIG by push. Conclusion: Self-administered subcutaneous immunoglobulin therapy by push is an effective and safe alternative therapy for patients with PID.

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