alexa Substituting Poly and Mono-unsaturated Fat for Dietary CarbohydrateReduces Hyperinsulinemia in Women with Polycystic Ovary Syndrome
ISSN: 2155-9600

Journal of Nutrition & Food Sciences
Open Access

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Research Article

Substituting Poly and Mono-unsaturated Fat for Dietary CarbohydrateReduces Hyperinsulinemia in Women with Polycystic Ovary Syndrome

Dalia P, Nicole C#, Cindy L, Susan C, Fahim A and McLaughlin T*

#Currently at the San Jose Medical Group: 2585 Samaritan Drive, San Jose, CA 95124, USA.

Division of Endocrinology, Stanford University School of Medicine, 300 Pasteur Drive, Rm S025 Stanford, CA, 94305-5103, USA.

*Corresponding Author:
McLaughlin T
Division of Endocrinology, Stanford University
School of Medicine, 300 Pasteur Drive
Rm S025, Stanford, CA 94305-5103
Tel: 650-723-3186
Fax: 650-725-7085;
E-mail: [email protected]

Received date: September 29, 2015 Accepted date: November 12, 2015 Published date: November 19, 2015

Citation: Dalia P, Nicole C, Cindy L, Susan C, Fahim A, et al. (2015) Substituting Poly and Mono-unsaturated Fat for Dietary Carbohydrate Reduces Hyperinsulinemia in Women with Polycystic Ovary Syndrome. J Nutr Food Sci 5:429. doi: 10.4172/2155-9600.1000429

Copyright: © 2015 Dalia P, et al. This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.



Objective: Hyperinsulinemia is a prevalent feature of Polycystic Ovary Syndrome (PCOS), contributing to metabolic and reproductive manifestations of the syndrome. Weight loss reduces hyperinsulinemia but weight regain is the norm, thus preventing long-term benefits. In the absence of weight loss, replacement of dietary carbohydrate (CHO) with mono/polyunsaturated fat reduces ambient insulin concentrations in non-PCOS subjects. The current study evaluated whether this dietary intervention could ameliorate hyperinsulinemia in women with PCOS.
Design/Setting/Patients: Obese women with PCOS (BMI 39 ± 7 kg/m2) and insulin resistance completed a crossover study (Stanford University Clinical Research Center) comparing two isocaloric diets, prepared by research dietitians, containing 60% CHO/25% fat versus 40% CHO/45% fat (both 15% protein and ≤ 7% saturated fat). After 3 weeks on each diet, day-long glucose, insulin, and fasting lipid/lipoproteins were measured.
Results: Day-long glucose did not differ according to diet. Day-long insulin concentrations were substantially (30%) and significantly lower on the low-CHO/higher fat diet. Beneficial changes in lipid profile were also observed.
Conclusions: Replacement of dietary CHO with mono/polyunsaturated fat yields clinically important reductions in day-long insulin concentrations, without adversely affecting lipid profile in obese, insulin-resistant women with PCOS. This simple and safe dietary intervention may constitute an important treatment for PCOS.


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