Successful Hyperbaric Oxygen Therapy with Thyrotropin-Releasing Hormone Therapy for Delayed Neuropsychiatric Sequelae after Acute Carbon Monoxide Poisoning: A Case Study
- *Corresponding Author:
- Minoru Takebayashi
Department of Psychiatry, National Hospital Organization (NHO)
Kure Medical Center and Chugoku Cancer Center, Japan
E-mail: [email protected]
Received Date: December 26, 2016; Accepted Date: January 12, 2017; Published Date: January 18, 2017
Citation: Omori W, Oga K, Itagaki K, Takebayashi M (2017) Successful Hyperbaric Oxygen Therapy with Thyrotropin-Releasing Hormone Therapy for Delayed Neuropsychiatric Sequelae after Acute Carbon Monoxide Poisoning: A Case Study. J Clin Case Rep 7:912. doi: 10.4172/2165-7920.1000912
Copyright: © 2017 Omori W, et al. This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.
Delayed neuropsychiatric sequelae (DNS) after acute carbon monoxide (CO) poisoning is a complication of CO intoxication. Hyperbaric oxygen (HBO) therapy is one of the only established treatments for CO poisoning, but as there is no specific treatment for DNS, the prognosis of DNS patients is generally poor. A 40-year-old male patient, following attempted suicide by CO poisoning, was referred to our department after having received HBO therapy at another hospital, but treatment had been subsequently discontinued due to patient agitation. The patient was diagnosed with DNS after acute CO poisoning, and we reinitiated HBO therapy. However, due to manifestation of symptoms of severe dementia, treatment was discontinued. After initiating thyrotropin-releasing hormone (TRH) therapy, psychiatric symptoms, such as difficulty in following instructions, improved, enabling the resumption of HBO therapy. Daily activities returned to premorbid levels following treatment. Thus, TRH therapy could be effective for patients with DNS due to acute CO poisoning who experience difficulty with HBO therapy.