Successful Pregnancy in Recurrent Thin Endometrium with New Uses for an Old Drug
|Xin Chen and Shi-ling Chen*|
|Center for Reproductive Medicine, Department of Gynecology and Obstetrics, Nanfang Hospital, Southern Medical University, Guangzhou, Guangdong, People’s Republic of China|
|*Corresponding Author :||Shi-ling Chen, M.D, Ph.D
Center for Reproductive Medicine
Department of Obstetrics and Gynecology
Nanfang Hospital, Southern Medical University
Guangzhou 510515, People’s Republic of China
Fax: 0086 2087280183
E-mail: [email protected]
|Received August 23, 2013; Accepted September 12, 2013; Published September 14, 2013|
|Citation: Chen X, Chen Sl (2013) Successful Pregnancy in Recurrent Thin Endometrium with New Uses for an Old Drug.J Fertil In Vitro IVF Worldw Reprod Med Genet Stem Cell Biol 1:110. doi:|
|Copyright: © 2013 Chen X, et al. This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.|
Objective: To analyze whether the use of tamoxifen is a feasible option in repeated unresponsive thin
endometrium (<6 mm) with standard treatment options.
Methods: Three consecutive women undergoing Frozen Embryo Transfer (FET) who, after standard endometrial
preparation, still showed thin endometrium (<6 mm). They were all given with tamoxifen treatment.
Results: Successful endometrial expansion to at least 7.7 mm after tamoxifen treatment in three patients
previously with thin endometrium in abandoned IVF cycles, natural cycles and extended estrogen treatment cycles with aspirin. All the three patients performed embryo-transfer, and they all conceived. One singleton stopped growing on gestational week 8. Two deliveries produced three healthy children.
Conclusion: In patients of recurrent thin endometrium, regardless of whether abandoned IVF cycles, natural cycles or extended estrogen treatment cycles with aspirin, tamoxifen treatment may be a successful alternative approach.