alexa Successful Treatment of Severe Psoriatic Arthritis and Psoriasis with Double Filtration Plasmapheresis | OMICS International | Abstract
ISSN: 2155-9899

Journal of Clinical & Cellular Immunology
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Case Report

Successful Treatment of Severe Psoriatic Arthritis and Psoriasis with Double Filtration Plasmapheresis

Xiaoxia Yu1*, Lei Zhang2 and Peng Zhang1
1 Department of Rheumatology and Immunology, Traditional Chinese Medicine-Western Medicine Hospital of Cangzhou of Hebei, China
2 Medical Unit, 66019 Troops of Chinese people's Liberation Army, Beijing, China
Corresponding Author : Dr. Xiaoxia Yu
Department of Rheumatology and Immunology
Traditional Chinese Medicine-Western Medicine Hospital of Cangzhou of Hebei. No.31 Yellow River West Road
Cangzhou 061001, Hebei, People’s Republic of China
Tel: 13513276959
Fax: 86-0317-2025774
E-mail: [email protected]
Received February 23, 2014; Accepted June 02, 2014; Published June 09, 2014
Citation: Yu X, Zhang L, Zhang P (2014) Successful Treatment of Severe Psoriatic Arthritis and Psoriasis with Double Filtration Plasmapheresis. J Clin Cell Immunol 5:222. doi:10.4172/2155-9899.1000222
Copyright: © 2014 Yu X, et al. This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.
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Psoriatic arthritis (PsA) is a chronic, progressive, inflammatory arthropathy associated with psoriasis. Traditional disease modifying anti-rheumatic drugs (DMARDs) have shown inconsistent and unsatisfactory results. Treatment with biological agents has shown different results. Despite the evident efficacy of biologic agents for psoriasis and psoriatic arthritis, there is an increase in psoriasis following biologic agents’ therapies. Psoriasis has no permanent cure and represents a lifelong burden for affected patients. We report herein a successful therapeutic approach for PsA with widespread psoriasis using double filtration plasmapheresis (DFPP) in a 25-year-old female patient. Two months after the first DFPP treatment, a remarkable normalization of the clinical appearance was achieved. During the 3 years follow-up, the patient has had no detectable disease, and a sustained clinical remission has been maintained for 2 years after the interruption of therapy. DFPP therapy led to the complete regression of the severe disease. Therefore, we consider the therapy as promising for treatment of PsA.


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