alexa Sudden Death of an Inpatient Due to Anaphylactoid React
ISSN: 2329-9126

Journal of General Practice
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Case Report

Sudden Death of an Inpatient Due to Anaphylactoid Reaction: The Importance of Determining Correct Cause of Death at Autopsy

Masahito Hitosugi*, Atsuko Matsumoto, Marin Takaso, Akari Takaya Uno, Takeshi Koseki and Genta Miyama
Department of Legal Medicine, Shiga University School of Medical Science, Shiga 520-2192, Japan
*Corresponding Author : Masahito Hitosugi, MD
Department of Legal Medicine
Shiga University of Medical Science, Tsukinowa
Seta, Otsu, Shiga 520-2192, Japan
Tel: +81-77-548-2200
E-mail: [email protected]
Received: February 24, 2016 Accepted: March 02, 2016 Published: March 10, 2016
Citation: Hitosugi M, Matsumoto A, Takaso M, Uno AT, Koseki T, et al. (2016) Sudden Death of an Inpatient Due to Anaphylactoid Reaction: The Importance of Determining Correct Cause of Death at Autopsy. J Gen Practice 4:239. doi:10.4172/2329-9126.1000239
Copyright: © 2016 Hitosugi M, et al. This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.


Under the revised Medical Service Law, in-depth investigations of unpredictable deaths in health facilities must be undertaken. To illustrate our suggested procedure for investigating the sudden death of inpatients, and to emphasize the importance of postmortem examinations, we discuss an unusual forensic autopsy case. An 82-year-old Japanese woman with a 17-year history of type 2 diabetes and angina pectoris suddenly died after the injection of a water-soluble, nonionic contrast medium called iso-hexol (Omnipaque). The forensic autopsy and postmortem blood examination revealed an elevated serum level of tryptase (242 μg/L), a normal serum levelof IgE (64 IU/mL) and 5076 μg/mL of iso-hexol, but no morphological evidence suggesting injury or disease. Therefore, the cause of death was confirmed as a fatal anaphylactoid reaction caused by the injected contrast medium. Although severely adverse reactions from nonionic contrast media are rare, patients should be observed carefully after administration of such compounds. This case also illustrates the importance of determining the correct cause of sudden death by performing an autopsy and subsequent analytical examinations. The possibility of anaphylactic/anaphylactoid reaction should be considered in all cases of sudden unexpected deaths in hospitals or clinics.


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