alexa Sudden Unexpected Death in Parkinson’s Disease and the Pharmacological Modulation of the Ca2+/cAMP Signaling Interaction: A Shot of Good News | OMICS International | Abstract
ISSN: 2168-975X

Brain Disorders & Therapy
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Short Communication

Sudden Unexpected Death in Parkinson’s Disease and the Pharmacological Modulation of the Ca2+/cAMP Signaling Interaction: A Shot of Good News

Afonso Caricati-Neto1, Fúlvio Alexandre Scorza2 ,Carla Alessandra Scorza2, Roberta Monterazzo Cysneiros3, Francisco Sandro Menezes- Rodrigues1, and Leandro Bueno Bergantin1*

1Department of Pharmacology, Universidade Federal de São Paulo (UNIFESP), São Paulo-SP, Brazil

2Discipline of Neuroscience, Universidade Federal de São Paulo (UNIFESP), São Paulo-SP, Brazil

3Laboratory of Neurobiology, Universidade Presbiteriana Mackenzie, São Paulo-SP, Brazil

*Corresponding Author:
Leandro Bueno Bergantin
Laboratory of Autonomic and Cardiovascular Pharmacology
Department of Pharmacology, Escola Paulista de Medicina
Universidade Federal de São Paulo (UNIFESP), Rua Pedro de Toledo
669-Vila Clementino, São Paulo-SP, Brazil
Tel: 551155764973
E-mail: [email protected]

Received Date: April 07, 2017; Accepted Date: April 18, 2017; Published Date: April 25, 2017

Citation: Caricati-Neto A, Scorza FA, Scorza CA, Cysneiros RM, Menezes- Rodrigues FS, et al. (2017) Sudden Unexpected Death in Parkinson’s Disease and the Pharmacological Modulation of the Ca2+/cAMP Signaling Interaction: A Shot of Good News. Brain Disord Ther 6: 231. doi: 10.4172/2168-975X.1000231

Copyright: © 2017 Caricati-Neto A, et al. This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.

Abstract

This discusses how pharmacological modulation of the Ca2+/cAMP signaling interaction could be an important neuroprotective and cardioprotective strategy to protect the dopaminergic neurons from cell death related to Parkinson’s disease (PD) and at the same time to prevent the cardiac collapse in sudden unexpected death in PD.

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