Suggestion to Upgrade the Canonical Concept of Translation
Jan Charles Biro*
HOMULUS FND, Los Angeles, CA, USA
- *Corresponding Author:
- Jan Charles Biro
Los Angeles, CA. USA
Tel: +1-213 627 6134
E-mail: [email protected]
Received Date: April 09, 2014; Accepted Date: May 12, 2014; Published Date: May 14, 2014
Citation: Biro JC (2014) Suggestion to Upgrade the Canonical Concept of Translation. J Proteomics Bioinform 7:112-120. doi: 10.4172/jpb.1000311
Copyright: © 2014 Biro JC. This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.
Background: This research was carried out to provide a summary of a series of bioinformatical observations between 2000 and 2014 concerning the structure of nucleic acids and codons, the interaction between codons and amino-acids and the general concept of translation.
Methods: Public sequence and structure databases and established methods of bioinformatics resources were utilized during these studies.
Results: These studies provided novel insights into the canonical concept of translation and suggest that: 1) codons have structure and the development and function of the 1st, 2nd, 3rd codon residues is different; 2) codon boundaries are physicochemically defined; 3) there is a stereo-chemical compatibility (fitting) between codons and coded amino acids; 4) codon redundancy in the Genetic Code (synonymous codons) provides folding (3D) information to protein syntheses, that is additional to the information requested to determine the sequence of aminoacids (primary or 2D structure); 5) there is a Proteomic Code in the redundant Genetic Code; 6) mRNA-s assist the co-translational folding of their own coded peptides i.e. they function as nucleic acid chaperons; 7) tRNA-s assist even the transfer of folding information from mRNA to proteins (tRNA cycle) in addition to their traditional role as adaptor between codons and amino acids.
Conclusions: Computational (statistical) studies, molecular modeling and theoretical biological considerations suggest the possibility and necessity to upgrade the canonical concept of translation. Traditional laboratory confirmation is requested.