alexa Supramolecular Facilities to Melanoma Cells B16F10 with Nanoparticles of a DEAE-Dextran-MMA Copolymer-Paclitaxel Complex
ISSN: 2157-7439

Journal of Nanomedicine & Nanotechnology
Open Access

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Research Article

Supramolecular Facilities to Melanoma Cells B16F10 with Nanoparticles of a DEAE-Dextran-MMA Copolymer-Paclitaxel Complex

Yuki Eshita1, Rui-Cheng Ji2, Masayasu Onishi3, Masaaki Mizuno4, Jun Yoshida5, Naoji Kubota6 and Yasuhiko Onishi3*

1Department of Infectious Disease Control, Faculty of Medicine, Oita University, 1-1 Idaigaoka, Hasama-machi, Yufu, Oita 879-5593, Japan

2Department of Human Anatomy, Oita University, Faculty of Medicine, Oita, 879-5593, Japan

3Ryujyu Science Corporation, 39-4 Kosora-cho, Seto, Aichi 489-0842, Japan

4The Center for Advanced Medicine and Clinical Research, Nagoya University Hospital, 65 Tsurumai-cho, Showa-ku, Nagoya, Aichi 466-8560, Japan

5Chubu Rosai Hospital, Japan Labour Health and Welfare Organization, 1-10-6 Komei, Minato-ku, Nagoya, Aichi 455-8530, Japan

6Department of Chemistry, Faculty of Medicine, Oita University, 1-1 Idaigaoka, Hasama-machi, Yufu, Oita 879-5593, Japan

*Corresponding Author:
Yasuhiko Onishi
Ryujyu Science Corporation
39-4 Kosora-cho, Seto
Aichi 489-0842, Japan
E-mail: vyx00545@nifty.ne.jp

Received Date: April 18, 2012; Accepted Date: May 14, 2012; Published Date: May 18, 2012

Citation: Eshita Y, Ji RC, Onishi M, Mizuno M, Yoshida J, et al. (2012) Supramolecular Facilities to Melanoma Cells B16F10 with Nanoparticles of a DEAE-Dextran-MMA Copolymer-Paclitaxel Complex. J Nanomed Nanotechol S5:002. doi:10.4172/2157-7439.S5-002

Copyright: © 2012 Eshita Y, et al. This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.

 

Abstract

A DEAE-dextran-MMA copolymer (DDMC)–paclitaxel complex was generated using paclitaxel as the guest and DDMC as the host. The resulting nanoparticles were 200-300 nm in diameter and are thought to be useful as an anti-cancer drug delivery system because of forming a stable polymeric micelle in water. The resistance of B16F10 melanoma cells to paclitaxel was confirmed using survival curve analysis. On the other hand, there is no resistance of melanoma cells to DDMC–paclitaxel complex. The DDMC–paclitaxel complex showed superior anti-cancer activity to paclitaxel alone. The cell death rate was determined using Michaelis–Menten Equations, as the complex promoted allosteric supramolecular reaction to tubulin. From our results, the DDMC–paclitaxel complex was not extensively degraded in cells, and achieved good efficacy as an intact supramolecular anti-cancer agent. The DDMC–paclitaxel complex showed high reactivity and specificity of anti-melanoma cells, depending on its supramolecular facilities. The DDMC/PTX complex will be considered to be not degraded in cells, and represents the efficacy as supramolecular intact such as artificial enzymes having substrate-selective. It should be possible for other anti-cancer agents to offer the amplify effect from this supramolecular complex. These supramolecular facilities to melanoma cells will be very helpful to overcome cancer diseases.

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