alexa Supramolecular Facilities to Melanoma Cells B16F10 with Nanoparticles of a DEAE-Dextran-MMA Copolymer-Paclitaxel Complex | OMICS International | Abstract
ISSN: 2157-7439

Journal of Nanomedicine & Nanotechnology
Open Access

Like us on:

OMICS International organises 3000+ Global Conferenceseries Events every year across USA, Europe & Asia with support from 1000 more scientific Societies and Publishes 700+ Open Access Journals which contains over 50000 eminent personalities, reputed scientists as editorial board members.

Open Access Journals gaining more Readers and Citations
700 Journals and 15,000,000 Readers Each Journal is getting 25,000+ Readers

This Readership is 10 times more when compared to other Subscription Journals (Source: Google Analytics)

Research Article

Supramolecular Facilities to Melanoma Cells B16F10 with Nanoparticles of a DEAE-Dextran-MMA Copolymer-Paclitaxel Complex

Yuki Eshita1, Rui-Cheng Ji2, Masayasu Onishi3, Masaaki Mizuno4, Jun Yoshida5, Naoji Kubota6 and Yasuhiko Onishi3*

1Department of Infectious Disease Control, Faculty of Medicine, Oita University, 1-1 Idaigaoka, Hasama-machi, Yufu, Oita 879-5593, Japan

2Department of Human Anatomy, Oita University, Faculty of Medicine, Oita, 879-5593, Japan

3Ryujyu Science Corporation, 39-4 Kosora-cho, Seto, Aichi 489-0842, Japan

4The Center for Advanced Medicine and Clinical Research, Nagoya University Hospital, 65 Tsurumai-cho, Showa-ku, Nagoya, Aichi 466-8560, Japan

5Chubu Rosai Hospital, Japan Labour Health and Welfare Organization, 1-10-6 Komei, Minato-ku, Nagoya, Aichi 455-8530, Japan

6Department of Chemistry, Faculty of Medicine, Oita University, 1-1 Idaigaoka, Hasama-machi, Yufu, Oita 879-5593, Japan

*Corresponding Author:
Yasuhiko Onishi
Ryujyu Science Corporation
39-4 Kosora-cho, Seto
Aichi 489-0842, Japan
E-mail: [email protected]

Received Date: April 18, 2012; Accepted Date: May 14, 2012; Published Date: May 18, 2012

Citation: Eshita Y, Ji RC, Onishi M, Mizuno M, Yoshida J, et al. (2012) Supramolecular Facilities to Melanoma Cells B16F10 with Nanoparticles of a DEAE-Dextran-MMA Copolymer-Paclitaxel Complex. J Nanomed Nanotechol S5:002. doi:10.4172/2157-7439.S5-002

Copyright: © 2012 Eshita Y, et al. This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.

Abstract

A DEAE-dextran-MMA copolymer (DDMC)–paclitaxel complex was generated using paclitaxel as the guest and DDMC as the host. The resulting nanoparticles were 200-300 nm in diameter and are thought to be useful as an anti-cancer drug delivery system because of forming a stable polymeric micelle in water. The resistance of B16F10 melanoma cells to paclitaxel was confirmed using survival curve analysis. On the other hand, there is no resistance of melanoma cells to DDMC–paclitaxel complex. The DDMC–paclitaxel complex showed superior anti-cancer activity to paclitaxel alone. The cell death rate was determined using Michaelis–Menten Equations, as the complex promoted allosteric supramolecular reaction to tubulin. From our results, the DDMC–paclitaxel complex was not extensively degraded in cells, and achieved good efficacy as an intact supramolecular anti-cancer agent. The DDMC–paclitaxel complex showed high reactivity and specificity of anti-melanoma cells, depending on its supramolecular facilities. The DDMC/PTX complex will be considered to be not degraded in cells, and represents the efficacy as supramolecular intact such as artificial enzymes having substrate-selective. It should be possible for other anti-cancer agents to offer the amplify effect from this supramolecular complex. These supramolecular facilities to melanoma cells will be very helpful to overcome cancer diseases.

Keywords

Peer Reviewed Journals
 
Make the best use of Scientific Research and information from our 700 + peer reviewed, Open Access Journals
International Conferences 2018-19
 
Meet Inspiring Speakers and Experts at our 3000+ Global Annual Meetings

Contact Us

Agri & Aquaculture Journals

Dr. Krish

[email protected]

+1-702-714-7001Extn: 9040

Biochemistry Journals

Datta A

[email protected]

1-702-714-7001Extn: 9037

Business & Management Journals

Ronald

[email protected]

1-702-714-7001Extn: 9042

Chemistry Journals

Gabriel Shaw

[email protected]

1-702-714-7001Extn: 9040

Clinical Journals

Datta A

[email protected]

1-702-714-7001Extn: 9037

Engineering Journals

James Franklin

[email protected]

1-702-714-7001Extn: 9042

Food & Nutrition Journals

Katie Wilson

[email protected]

1-702-714-7001Extn: 9042

General Science

Andrea Jason

[email protected]

1-702-714-7001Extn: 9043

Genetics & Molecular Biology Journals

Anna Melissa

[email protected]

1-702-714-7001Extn: 9006

Immunology & Microbiology Journals

David Gorantl

[email protected]

1-702-714-7001Extn: 9014

Materials Science Journals

Rachle Green

[email protected]

1-702-714-7001Extn: 9039

Nursing & Health Care Journals

Stephanie Skinner

[email protected]

1-702-714-7001Extn: 9039

Medical Journals

Nimmi Anna

[email protected]

1-702-714-7001Extn: 9038

Neuroscience & Psychology Journals

Nathan T

[email protected]

1-702-714-7001Extn: 9041

Pharmaceutical Sciences Journals

Ann Jose

[email protected]

1-702-714-7001Extn: 9007

Social & Political Science Journals

Steve Harry

[email protected]

1-702-714-7001Extn: 9042

 
© 2008- 2018 OMICS International - Open Access Publisher. Best viewed in Mozilla Firefox | Google Chrome | Above IE 7.0 version
Leave Your Message 24x7