Supraphysiological Free Radical Levels and their Pathogenesis in Male Infertility
Dinesh V, Shamsi MB and Dada R*
Laboratory for Molecular Reproduction and Genetics, Department of Anatomy, All India Institute of Medical Sciences, New Delhi-110029, India
- *Corresponding Author:
- Dada R
Department of Anatomy
All India Institute of Medical Sciences
New Delhi-110029, India
E-mail: [email protected]
Received date: October 30, 2012; Accepted date: November 14, 2012; Published date: November 24, 2012
Citation: Dinesh V, Shamsi MB, Dada R (2012) Supraphysiological Free Radical Levels and their Pathogenesis in Male Infertility. Reprod Sys Sexual Disorders 1:114. doi:10.4172/2161-038X.1000114
Copyright: © 2012 Dinesh V, et al. This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.
Oxidative stress is an important aetiological factor which leads to sperm DNA damage and infertility. It damages all biomolecules and both mitochondrial and nuclear DNA and adversely affects sperm membrane fluidity and motility. This acts like a biological safeguard however use of such sperm for ART/ICSI can lead to pre and post implantation losses, major and minor congenital malformations and even childhood cancer. Thus it is important to know the causes of oxidative stress and how the levels of free radicals be maintained at physiological levels when they are beneficial for normal function. It is also important to develop techniques to identity cases with high free radical levels and also adopt certain life style measures which can minimise oxidative stress and improve male reproductive health.