Surfactant-based Transdermal System for Fluconazole Skin DeliveryHilris Rocha e Silva1, Gabriela Marielli da Luz1, Cínthia Yuka Satake1, Bruna Carolina Correa1, Victor Hugo Vitorino Sarmento2, Georgino Honorato de Oliveira1, Flávia Chiva Carvalho1,3, Marlus Chorilli1 and Maria Palmira Daflon Gremião1*
- *Corresponding Author:
- Maria Palmira Daflon Gremião
Universidade Estadual Paulista UNESP
School of Pharmaceutical Sciences
Drugs and medicines Department
Rodovia Araraquara-Jaú, Km 01
14801-902, Araraquara, SP, Brazil
E-mail: [email protected]
Received Date: August 16, 2014; Accepted Date: October 06, 2014; Published Date: October 14, 2014
Citation: Silva HR, Luz GM, Satake CY, Correa BC, Sarmento VHV, et al. (2014) Surfactant-based Transdermal System for Fluconazole Skin Delivery. J Nanomed Nanotechnol 5:231. doi:10.4172/2157-7439.1000231
Copyright: © 2014 Silva HR, et al. This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.
The development of a controlled-release dosage form of antifungals is of crucial importance in view of the side-effects of conventional oral and intravenous treatments of Sporotrichosis. In this study, systems composed of polyoxypropylene (5) polyoxyethylene (20) cetyl alcohol (PPG-5-CETETH-20) as a surfactant, oleic acid as an oil phase, and water were developed as a possible fluconazole transdermal drug delivery system. The systems were characterised by polarised light microscopy (PLM), SAXS, and rheological analysis, followed by cellular and histological analyses, in vitro release assays, and ex vivo skin permeation and retention studies using porcine ear tissue and a Franz diffusion cell. PLM and SAXS results indicated that the mixtures of surfactant, oil and water formed micellar and lamellar phases. The incorporation of fluconazole in these systems was greater than in water and conventional dosage forms. Micellar systems behave as Newtonian fluids, being more viscous than elastic in rheological analysis, and lamellar phases behave as pseudoplastic fluids with high elastic moduli. In vitro and in vivo biological assays showed that the formulations did not affect normal cell macrophages and did not promote skin irritation. The release profile indicated that fluconazole could be released in a controlled manner. It was found that the systems enhanced drug permeation and skin retention by changing only the composition of the components in the formulations. Therefore, PPG-5-CETETH-20- based systems have great potential as transdermal systems with different structural and rheological characteristics for Sporotrichosis treatment using antifungal drugs.