Surgery for Intracranial Tumours in the First Five Years of Life- A Single Institution Consecutive Series of 68 Children
- *Corresponding Author:
- Tryggve Lundar, MD, PhD
Oslo University Hospital HF, Rikshospitalet
Department of Neurosurgery, OSLO, Norway
Tel: +47 23 07 43 02
Fax: +47 23 07 43 10
E-mail: [email protected]
Received date: August 25, 2014; Accepted date: October 30, 2014; Published date: November 07, 2014
Citation: Pernes L, Sommerfelt L, Lundar T, Wesenberg F (2014) Surgery for Intracranial Tumours in the First Five Years of Life- A Single Institution Consecutive Series of 68 Children. Surgery Curr Res 4:209. doi: 10.4172/2161-1076.1000209
Copyright: © 2014 Pernes L, et al. This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.
Thirty-four females and thirty-four males aged 0-4 years were primarily operated for a brain tumour during the years 2005 through 2011. Twenty-two of the tumours were infratentorial and forty-six were supratentorial. Tumours presented more frequently in the first year of life (n=21), and 19 of these infants had a supratentorial tumour. In the 1-4 years age group (n=47), 27 children had supratentorial tumours. Twenty-three of the tumours were high-grade tumours, PNET (primitive neuroectodermal tumour) and ependymomas being most frequent. Forty-five were lowgrade, mostly being astrocytomas. The clinical presentation was heterogeneous with a wide range of symptoms. Conclusions: Tumours presented more frequently in the first year of life (31%), and 90.5% of these infants had a supratentorial tumour, in comparison to 57% in the age group 1-4 years. Five year overall survival rate was 86,6% in children with low-grade tumours opposed to 61% among children with high-grade tumours. The aim of primary surgery with GTR (gross total resection) was achieved in 36 children leading to 94 % overall survival (OS) after 2-8 years follow up. In the 32 children who had only a partial resection or a biopsy, OS was 66 %.