alexa Sustained Disease-Activity-Free Status in a Woman with Relapsing-Remitting Multiple Sclerosis Treated with Antiretroviral Therapy for Human Immunodeficiency Virus Type 1 Infection | Abstract
ISSN: 2376-0389

Journal of Multiple Sclerosis
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Case Report

Sustained Disease-Activity-Free Status in a Woman with Relapsing-Remitting Multiple Sclerosis Treated with Antiretroviral Therapy for Human Immunodeficiency Virus Type 1 Infection

Francesco Maulucci*, Myriam Schluep and Cristina Granziera
Service de Neurologie, Département des Neurosciences Cliniques, CHUV, Lausanne, Switzerland
*Corresponding Author : Francesco Maulucci
Service de Neurologie, Centre Hospitalier Universitaire Vaudois
Rue du Bugnon 46, 1011 Lausanne, Switzerland
Tel: +41795568452
Fax: +41213141290
E-mail: [email protected]
Received: July 30, 2015; Accepted: September 03, 2015; Published: September 10, 2015
Citation: Maulucci F, Schluep M, Granziera C (2015) Sustained Disease-Activity- Free Status in a Woman with Relapsing-Remitting Multiple Sclerosis Treated with Antiretroviral Therapy for Human Immunodeficiency Virus Type 1 Infection. J Mult Scler (Foster City) 2:152. doi:10.4172/2376-0389.1000152
Copyright: © 2015 Maulucci F, et al. This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.

Abstract

A negative association between human immunodeficiency virus (HIV) Infection and multiple sclerosis (MS) is expected, as MS pathogenesis is triggered by auto-reactive T-cells, which are depressed in case of HIV Infection. Furthermore, there is increasing evidence that HIV-Infected MS patients may benefit from antiretroviral therapy.

We report the case of a woman suffering from relapsing-remitting MS (RR-MS) who contracted HIV-1 Infection while she was treated with low-dose interferon (IFN) beta-1a since five years. With combination antiretroviral therapy (cART) in addition to IFN beta-1a, the patient had normal CD4+ cell counts, undetectable viral load, and no more clinical and radiological evidence of MS activity.

The reason why HIV Infection has a protective role for developing MS, and how antiretroviral therapy is effective in modifying MS course are intriguing questions which need further investigations.

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