Sustained Disease-Activity-Free Status in a Woman with Relapsing-Remitting Multiple Sclerosis Treated with Antiretroviral Therapy for Human Immunodeficiency Virus Type 1 Infection
|Francesco Maulucci*, Myriam Schluep and Cristina Granziera|
|Service de Neurologie, Département des Neurosciences Cliniques, CHUV, Lausanne, Switzerland|
|*Corresponding Author :||Francesco Maulucci
Service de Neurologie, Centre Hospitalier Universitaire Vaudois
Rue du Bugnon 46, 1011 Lausanne, Switzerland
E-mail: [email protected]
|Received: July 30, 2015; Accepted: September 03, 2015; Published: September 10, 2015|
|Citation: Maulucci F, Schluep M, Granziera C (2015) Sustained Disease-Activity- Free Status in a Woman with Relapsing-Remitting Multiple Sclerosis Treated with Antiretroviral Therapy for Human Immunodeficiency Virus Type 1 Infection. J Mult Scler (Foster City) 2:152. doi:10.4172/2376-0389.1000152|
|Copyright: © 2015 Maulucci F, et al. This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.|
A negative association between human immunodeficiency virus (HIV) Infection and multiple sclerosis (MS) is expected, as MS pathogenesis is triggered by auto-reactive T-cells, which are depressed in case of HIV Infection. Furthermore, there is increasing evidence that HIV-Infected MS patients may benefit from antiretroviral therapy.
We report the case of a woman suffering from relapsing-remitting MS (RR-MS) who contracted HIV-1 Infection while she was treated with low-dose interferon (IFN) beta-1a since five years. With combination antiretroviral therapy (cART) in addition to IFN beta-1a, the patient had normal CD4+ cell counts, undetectable viral load, and no more clinical and radiological evidence of MS activity.
The reason why HIV Infection has a protective role for developing MS, and how antiretroviral therapy is effective in modifying MS course are intriguing questions which need further investigations.