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ISSN: 2329-8790

Journal of Hematology & Thromboembolic Diseases
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Research Article

Sustained Responses following Treatment with Romiplostim in Immune Thrombocytopenia: A Single-Centre Experience

Drew Provan1*, Louise Taylor2, Raghava Nandigham1, Umesh Doobaree1, Pallavi Kalkur2 and Adrian C Newland1
1Barts and The London School of Medicine and Dentistry, London, UK
2Barts Health NHS Trust, London, El IBB, London, UK
Corresponding Author : Drew Provan
Barts and The London School of Medicine and Dentistry
London, UK
Tel: 92032460339
E-mail: [email protected]
Received May 27, 2014; Accepted June 16, 2014; Published June 25, 2014
Citation: Provan D, Taylor L, Nandigham R, Doobaree U, Kalkur P, et al. (2014) Sustained Responses following Treatment with Romiplostim in Immune Thrombocytopenia: A Single-Centre Experience. J Hematol Thrombo Dis 2:147. doi: 10.4172/2329-8790.1000147
Copyright: © 2014 Provan D, et al. This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.
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Abstract

Background: Romiplostim is a thrombopoietin receptor agonist which is useful for the treatment of adults with chronic immune thrombocytopenia. This class of treatment is regarded as palliative, raising platelet counts whilst patients are receiving romiplostim, with the expectation that platelets will return to baseline after stopping therapy. Anecdotal reports have suggested that some patients show unexpected longer term responses when off treatment. Design: We examined the outcomes for 21 consecutively-treated adult patients at our center to determine whether any patients had sustained responses after stopping romiplostim. A platelet count of ≥ 100 x 109/L was considered a complete response, and from 50–100×109/L this was considered a partial response. If the response after stopping romiplostim lasted 6 months or more this was considered a durable response.

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