alexa Suvorexant as an Adjunctive Treatment for Insomnia Prior to Discontinuation of Benzodiazepines: Prevention of Withdrawal Syndrome and Rebound Insomnia
ISSN: 2168-975X

Brain Disorders & Therapy
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Research Article

Suvorexant as an Adjunctive Treatment for Insomnia Prior to Discontinuation of Benzodiazepines: Prevention of Withdrawal Syndrome and Rebound Insomnia

Sachiko Yokoyama1, Toshiaki Tsuneoka1, Koji Hori2*, Osamu Takashio1, Satoru Sugisawa3, Sumiko Nakamura3, Nobuyuki Saga1, Eriko Ono1, and Akira Iwanami1

1Department of Psychiatry, Showa University, Karasuyama Hospital, Japan

2Department of Psychiatry, St. Marianna University, School of Medicine, Japan

3Department of Hospital Pharmaceutics, School of Pharmacy, Showa University, Japan

*Corresponding Author:
Koji Hori
Department of Psychiatry, St. Marianna University
School of Medicine, Sugao 2-16-1
Kawasaki Miyamae-Ku, Kanagawa, 2160015, Japan
Tel: +81449778111
Fax: +81449750608
E-mail: [email protected]

Received Date: April 05, 2017; Accepted Date: April 27, 2017; Published Date: May 01, 2017

Citation: Yokoyama S, Tsuneoka T, Hori K, Takashio O, Sugisawa S, et al. (2017) Suvorexant as an Aadjunctive Treatment for Insomnia Prior to Discontinuation of Benzodiazepines: Prevention of Withdrawal Syndrome and Rebound Insomnia Brain Disord Ther 6:233. doi: 10.4172/2168-975X.1000233

Copyright: © 2017 Yokoyama S, et al. This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.



Objective: To examine whether concurrent use of benzodiazepines (BZDs) affects continuation rates for suvorexant.

Background: A wider range of different BZDs and similar drugs are available on prescription in Japan than in other countries, making prescribing more complicated. Safety has only been indicated for the use of suvorexant as monotherapy in primary insomnia. Understanding the safety of concurrent use of suvorexant with other drugs could simplify prescriptions for insomnia.

Material and Methods: We obtained the prescription records of patients who were hospitalized or attended outpatient appointments, and were prescribed suvorexant, at Showa University Karasuyama Hospital between November 2014 and April 2016.

Results: Patients prescribed suvorexant were retrospectively surveyed for drug discontinuation as indicated in their medical records. Among 326 patients who were prescribed suvorexant during the study period, use of the medication could not be confirmed in 20 patients, who were therefore excluded. This left a final study sample of 306 patients. We could track 289 patients up until day 90. There were no significant differences observed between patients treated with a BZD combination (54.0%) and those not treated with a combination (46.0%) in terms of medication continuation across the 90-day observation period (Exp(B)=1.304, 95% confidence interval, CI: 0.827-2.057, P=0.253). The rates of side effect onset were also not significantly different.

Conclusion: We observed that concurrent use of BZD was not related to withdrawal from suvorexant in patients being treated for insomnia.


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