Synbiotics, Surgical Infection and Colonization ResistanceShunichiro Komatsu*
Department of Gastroenterological Surgery, Aichi Medical University, Nagakute, Aichi, Japan
- *Corresponding Author:
- Shunichiro Komatsu, MD
Department of Gastroenterological Surgery
Aichi Medical University
Nagakute, Aichi 480-1195, Japan
E-mail: [email protected]
Received date: February 17, 2016; Accepted date: April 08, 2016; Published date: April 15, 2016
Citation: Komatsu S (2016) Synbiotics, Surgical Infection and Colonization Resistance. Clin Microbiol 5:243. doi:10.4172/2327-5073.1000243
Copyright: © 2016 Komatsu S. This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.
In our recent randomized controlled study to assess the effect of perioperative oral administration of synbiotics on surgical outcome in patients undergoing laparoscopic colorectal resection, the efficacy of synbiotics as a treatment to reduce the incidence of infectious complications was not validated. However, this study incorporated molecularbased methods and a large sample size, and microbiological examinations showed that dysbiosis induced by surgery was greatly improved by perioperative synbiotic treatment, resulting in the decrease of potentially pathogenic bacteria, such as Clostridium difficile. This study also provided novel evidence that could explain, in part, the mechanisms whereby probiotics enhance colonization resistance in the gastrointestinal tract.