alexa Synergism between Antiplasmid Promethazine and Antibiotics In Vitro and InVivo
ISSN: 2168-9547

Molecular Biology: Open Access
Open Access

OMICS International organises 3000+ Global Conferenceseries Events every year across USA, Europe & Asia with support from 1000 more scientific Societies and Publishes 700+ Open Access Journals which contains over 50000 eminent personalities, reputed scientists as editorial board members.

Open Access Journals gaining more Readers and Citations

700 Journals and 15,000,000 Readers Each Journal is getting 25,000+ Readers

This Readership is 10 times more when compared to other Subscription Journals (Source: Google Analytics)

Research Article

Synergism between Antiplasmid Promethazine and Antibiotics In Vitro and InVivo

Joseph Molnár1*, Yvette Mándi1, Gabriella Spengler1, Leonard Amaral1,2, Ibolya Haszon3, Sándor Turi3 and Miklós Kásler4

1Department of Medical Microbiology and Immunobiology, University of Szeged, Szeged, Hungary

2Travel Medicine of the CMDT [Centro de Malaria e Doencas Tropicais], Instituto de Medicina Tropical and Higiene, New University of Lisbon, Lisbon, Portugal

3Department of Pediatrics, University of Szeged, Szeged Hungary

4National Institute of Oncology, Budapest, Hungary

*Corresponding Author:
Joseph Molnár, MD, Ph.D
D.Sc. Institute of Medical Microbiology and Immunobiology
University of Szeged; H-6720 Szeged, Hungary
Tel: +36 62545115
Fax: +36 62545113
E-mail: [email protected]

Received date: May 30, 2014; Accepted date: August 21, 2014; Published date: August 25, 2014

Citation: Joseph Molnár, Yvette Mándi, Gabriella Spengler, Leonard Amara, Ibolya Haszon et al. (2014) Synergism between Antiplasmid Promethazine and Antibiotics In Vitro and In Vivo. Mol Biol 3:119. doi:10.4172/2168-9547.1000119

Copyright: © 2014 Joseph Molnár et al. This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.

Abstract

Four large groups of antibiotics were developed for different targets of bacterial cells which differ from those of human cells. Uncontrolled use of antibiotics, resistance soon followed. Today, the majorities of bacterial infections are caused by multidrug resistant bacterial isolates and result in serious treatment difficulties. The main cause for antibiotic resistance is the acquisition of plasmids which carry antibiotic resistant genes. These extra-chromosomal genetic elements can be eliminated by phenothiazines from antibiotic resistant bacteria by the selective inhibition of plasmid replication over that of the plasmid carrying bacterium at three different levels or steps as follows: 1. replication of plasmid DNA is destabilized due to the drug induced relaxation of super-helical structure of replicative form of plasmid DNA; 2. inhibition of partition of plasmid DNA during the cell division blocks the rolling circle type of distribution of plasmid into the two daughter cells; 3. inhibition of re-infection of plasmid less bacteria by blocking conjugation. The medical importance of in vivo anti-plasmid effects of promethazine was shown, and resulted in synergism between promethazine and gentamycin treatment. The frequently recurring pyelonephritis was cured in children. All the in vivo studies employing promethazine described in this review have been approved by Ethics Committee of Clinic and Hospital where therapy took place. The significance of plasmid elimination in vitro provides a method to isolate plasmid-free bacteria for biotechnology without any risks of mutation and opens a new perspective in rational drug design against multidrug resistant bacterial infections

Share This Page

Additional Info

Loading
Loading Please wait..
 
Peer Reviewed Journals
 
Make the best use of Scientific Research and information from our 700 + peer reviewed, Open Access Journals
International Conferences 2017-18
 
Meet Inspiring Speakers and Experts at our 3000+ Global Annual Meetings

Contact Us

Agri & Aquaculture Journals

Dr. Krish

[email protected]

1-702-714-7001Extn: 9040

Biochemistry Journals

Datta A

[email protected]

1-702-714-7001Extn: 9037

Business & Management Journals

Ronald

[email protected]

1-702-714-7001Extn: 9042

Chemistry Journals

Gabriel Shaw

[email protected]

1-702-714-7001Extn: 9040

Clinical Journals

Datta A

[email protected]

1-702-714-7001Extn: 9037

Engineering Journals

James Franklin

[email protected]

1-702-714-7001Extn: 9042

Food & Nutrition Journals

Katie Wilson

[email protected]

1-702-714-7001Extn: 9042

General Science

Andrea Jason

[email protected]

1-702-714-7001Extn: 9043

Genetics & Molecular Biology Journals

Anna Melissa

[email protected]

1-702-714-7001Extn: 9006

Immunology & Microbiology Journals

David Gorantl

[email protected]

1-702-714-7001Extn: 9014

Materials Science Journals

Rachle Green

[email protected]

1-702-714-7001Extn: 9039

Nursing & Health Care Journals

Stephanie Skinner

[email protected]

1-702-714-7001Extn: 9039

Medical Journals

Nimmi Anna

[email protected]

1-702-714-7001Extn: 9038

Neuroscience & Psychology Journals

Nathan T

[email protected]

1-702-714-7001Extn: 9041

Pharmaceutical Sciences Journals

Ann Jose

[email protected]

1-702-714-7001Extn: 9007

Social & Political Science Journals

Steve Harry

[email protected]

1-702-714-7001Extn: 9042

 
© 2008- 2017 OMICS International - Open Access Publisher. Best viewed in Mozilla Firefox | Google Chrome | Above IE 7.0 version
adwords