Synthesis and Anticancer Activity of Some Novel Fused Nicotinonitrile DerivativesReda M Fekry1, Hassan A El-sayed1*, Mohamed G Assy1, Asad Shalby1 and Abdussattar S Mohamed2
- *Corresponding Author:
- Hassan A El-sayed
Department of Chemistry, Faculty of Science
Zagazig University, Zagazig, Egypt
E-mail: [email protected]
Received Date: September 29, 2016; Accepted Date: October 10, 2016; Published Date: October 29, 2016
Citation: Fekry RM, El-sayed HA, Assy MG, Shalby A, Mohamed AS (2016) Synthesis and Anticancer Activity of Some Novel Fused Nicotinonitrile Derivatives. Organic Chem Curr Res 5:171. doi: 10.4172/2161-0401.1000171
Copyright: © 2016 Fekry RM, et al. This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.
A series of fused nicotinonitrile derivatives was synthesized by reaction of 2,6-dioxonicotinonitrile derivative 1 with different electrophilic reagents. Reaction of pyridone 1 with benzyledine derivative 2, 3 and 7 afforded pyrano[2,3-b] pyridine 4 and 11 derivatives, respectively. Upon reaction of pyridone 1 with α,β-unsaturated carbonyl compounds and benzoyl isothiocyanate gave the corresponding pyridine derivatives 11-13 and 16, respectively, Morevere sulfurization and selenation of pyridone 1 with sulfur and selenium in the presence of triethyl amine afforded the fused pyridine 14 and 15, respectively. The structure of the new synthesized compounds was elucidated by IR, NMR and elemental analysis. Some of new synthesized pyridines were screnned for anticancer activity.