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ISSN: 2161-0444

Medicinal Chemistry
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Research Article

Synthesis and Anti-Cancer Evaluation of Spiro-indolinone Derivatives

Liang Hong1, Jie Tong2, Guangliang Yu1, Chunqi Hu1,2*

1Yongning Pharma, Taizhou, PR China

2College of Chemistry and Chemical Engineering, Shaoxing University, Shaoxing, PR China

*Corresponding Author:
Chunqi Hu
College of Chemistry and Chemical Engineering
Shaoxing University, Shaoxing, PR China
Tel: +8657588341521
Fax: +8657588341521
E-mail: [email protected]

Received date: April 13, 2017; Accepted date: April 17, 2017; Published date: April 21, 2017

Citation: Hong L, Tong J, Yu G, Hu C (2017) Synthesis and Anti-Cancer Evaluation of Spiro-indolinone Derivatives. Med Chem (Los Angeles) 7:110-116. doi: 10.4172/2161-0444.1000440

Copyright: © 2017 Hong L, et al. This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.

Abstract

A series of spiro-indolin-2-one derivatives were designed and synthesized as p53-MDM2 binding inhibitors. Though p53-MDM2 binding inhibitory and activities against p53 wild-type cell lines of most compounds were not that promising, some obtained structures showed moderate to strong inhibitory activities (IC50<0.08 μM) against p53 mutant cell lines (SW620), suggesting that these compounds may have different modes of action to p53 pathway, further studies on treatment of p53 mutant tumors are under investigation.cc

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