alexa Synthesis and Antimicrobial Activity of Novel 3,7-Disub
ISSN: 2161-0444

Medicinal Chemistry
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Research Article

Synthesis and Antimicrobial Activity of Novel 3,7-Disubstituted 2H-1- Benzopyran-2-Ones

Shailesh K1*, Devdutt C2 and Devi Prasad S3

1Department of Applied Chemistry, Babasaheb Bhimrao Ambedkar University (BBAU), Lucknow, Uttar Pradesh, India

2Department of Applied Chemistry, Amity School of Applied Sciences, Amity University Uttar Pradesh, Lucknow Campus, Lucknow, Uttar Pradesh, India

3Medicinal and Process Chemistry Division, CSIR - Central Drug Research Institute (CDRI), Lucknow, Uttar Pradesh, India

*Corresponding Author:
Shailesh Kumar
Department of Applied Chemistry
Babasaheb Bhimrao Ambedkar University (BBAU)
Lucknow-226 025, Uttar Pradesh, India
Tel: 8005375720
Fax: 8005375720
E-mail: [email protected]

Received date: April 10, 2017; Accepted date: April 18, 2017; Published date: April 24, 2017

Citation: Shailesh K, Devdutt C, Devi Prasad S (2017) Synthesis and Antimicrobial Activity of Novel 3,7-Disubstituted 2H-1-Benzopyran-2-Ones. Med Chem (Los Angeles) 7:857-864. doi: 10.4172/2161-0444.1000442

Copyright: © 2017 Shailesh K, et al. This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.



2H-1-benzopyran-2-one (Coumarin), an important oxygen heterocyclic scaffold, widely distributed throughout the plant kingdom, displayed a wide range of potential biological activities such as anti-microbial, anti-inflammatory and antioxidant activities. In this paper, we have synthesized a novel class of 3,7-disubstituted 2H-1-benzopyran- 2-one derivatives (3aa-3hb) bearing a basic ether side chain at C-7 and a substituted phenyl ring at C-3 of the coumarin ring. These compounds have been evaluated for anti-microbial (antibacterial/antifungal) activities. Some of the compounds 3ac, 3ae, 3bb, 3bc have shown significant anti-fungal activities against selective strains. Compound 3ae and 3bc with the MIC values of 1.56 μg/mL displayed better antifungal activity than fluconazole against Trichophyton mentagrophytes.


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