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ISSN: 2161-0444

Medicinal Chemistry
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  • Research Article   
  • Med chem (Los Angeles) 2017, Vol 7(11): 361
  • DOI: 10.4172/2161-0444.1000481

Synthesis and Antimicrobial Activity of Pyrazolyl Triazoles

Gaddam Lakshmi Teja1, Donthamsetty Venkata Sowmya1, Adivireddy Padmaja1, Vasikarla Kamala Prasad2 and Venkatapuram Padmavathi1*
1Department of Chemistry, Sri Venkateswara University, Tirupati, Andhra Pradesh, India
2Denisco Chemistry Private Limited, , Hyderabad, Telangana, India
*Corresponding Author : Venkatapuram Padmavathi, Department of Chemistry, Sri Venkateswara University, Tirupati-517 502, Andhra Pradesh, India, Tel: +918772249666303, Email: [email protected]

Received Date: Nov 21, 2017 / Accepted Date: Nov 25, 2017 / Published Date: Nov 30, 2017

Abstract

Pyrazolyl triazoles (5) were prepared by 1,3-dipolar cycloaddition of diazomethane to Schiff base - 3-ethynyl- N-(heteroarylmethylene)aniline (3), followed by oxidation with I2 in DMSO and studied their antimicrobial activity. The pyridine and dichloropyridine substituted compounds 3d, 5c and 5d are potential antibacterial agents against Bacillus subtilis and 3d is a potential antifungal agent against Penicillium chrysogenum.

Keywords: Schiff base; Pyrazole; Triazole; Antimicrobial activity

Citation: Teja GL, Sowmya DV, Padmaja A, Prasad VK, Padmavathi V, et al. (2017) Synthesis and Antimicrobial Activity of Pyrazolyl Triazoles. Med Chem (Los Angeles) 7:361-367. Doi: 10.4172/2161-0444.1000481

Copyright: © 2017 Teja GL, et al. This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.

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