Synthesis and Antimicrobial Activity of Pyrazolyl Triazoles
Received Date: Nov 21, 2017 / Accepted Date: Nov 25, 2017 / Published Date: Nov 30, 2017
Pyrazolyl triazoles (5) were prepared by 1,3-dipolar cycloaddition of diazomethane to Schiff base - 3-ethynyl- N-(heteroarylmethylene)aniline (3), followed by oxidation with I2 in DMSO and studied their antimicrobial activity. The pyridine and dichloropyridine substituted compounds 3d, 5c and 5d are potential antibacterial agents against Bacillus subtilis and 3d is a potential antifungal agent against Penicillium chrysogenum.
Keywords: Schiff base; Pyrazole; Triazole; Antimicrobial activity
Citation: Teja GL, Sowmya DV, Padmaja A, Prasad VK, Padmavathi V, et al. (2017) Synthesis and Antimicrobial Activity of Pyrazolyl Triazoles. Med Chem (Los Angeles) 7:361-367. Doi: 10.4172/2161-0444.1000481
Copyright: © 2017 Teja GL, et al. This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.
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